Effects of non-stationary blur on texture biomarkers of bone using Ultra-High Resolution CT.
Effects of non-stationary blur on texture biomarkers of bone using Ultra-High Resolution CT.
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使用超高分辨率 CT 研究非平稳模糊对骨纹理生物标志物的影响。
DOI：
10.1117/12.2654304
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Zbijewski,W
中科院分区：
文献类型：
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作者：
Shi,G;QuevedoGonzalez,FJ;Breighner,RE;Carrino,JA;Siewerdsen,JH;Zbijewski,W
PurposeTo使用最近推出的超高分辨率CT（UHR CT）推进骨质量放射组学模型的发展，我们研究了骨小梁纹理特征的扫描间再现性，以空间变化的方位角和径向模糊与焦点伸长和机架rotation.MethodsThe UHR CT系统具有250 × 250 μm探测器像素和0.4 × 0.5 mm焦点的X射线源。据报告，该器械的细节可视化可达约150 μm。在UHR CT上对尸体股骨在视野内的三个径向位置进行成像：0 cm（等中心点），距离等中心点9 cm和距离等中心点18 cm;我们预计非平稳模糊会随着径向位移的增加而恶化。灰度共生（GLCM）和灰度游程长度（GLRLM）纹理特征提取自237个感兴趣的骨小梁区域（ROI，5 cm直径），这些区域放置在不同班次获得的扫描中的股骨头中的相应位置。我们评估了一致性相关系数（CCC）之间的纹理特征在0厘米（参考），在9厘米和18厘米。我们还研究了空间变化的模糊是否影响K-均值聚类的骨小梁ROI的纹理features.ResultsThe平均CCC（对0厘米的参考）为GLCM和GLRM功能为~0.7在9厘米。在18 cm处，GLCM的平均CCC降至约0.17，GLRM降至约0.26。非平稳模糊被纳入松质骨的放射组学特征中，导致不同径向位置之间的小梁ROI聚类不一致：一个对应的交并重叠0 cm和9 cm之间的（最相似的）簇移位> 70%，但是对于0 cm和18 cm偏移之间的大多数对应簇，下降到<60%。骨小梁纹理特征在UHR CT中的扫描再现性，特别是对于距离等中心<15 cm的位置。在应用于诸如髋关节的外周身体部位之前，可能需要对来自等中心处的UHR CT测量的骨质量放射组学模型进行修订。
PurposeTo advance the development of radiomic models of bone quality using the recently introduced Ultra-High Resolution CT (UHR CT), we investigate inter-scan reproducibility of trabecular bone texture features to spatially-variant azimuthal and radial blurs associated with focal spot elongation and gantry rotation.MethodsThe UHR CT system features 250x250 μm detector pixels and an x-ray source with a 0.4x0.5 mm focal spot. Visualization of details down to ~150 μm has been reported for this device. A cadaveric femur was imaged on UHR CT at three radial locations within the field-of-view: 0 cm (isocenter), 9 cm from the isocenter, and 18 cm from the isocenter; we expect the non-stationary blurs to worsen with increasing radial displacement. Gray level cooccurrence (GLCM) and gray level run length (GLRLM) texture features were extracted from 237 trabecular regions of interest (ROIs, 5 cm diameter) placed at corresponding locations in the femoral head in scans obtained at the different shifts. We evaluated concordance correlation coefficient (CCC) between texture features at 0 cm (reference) and at 9 cm and 18 cm. We also investigated whether the spatially-variant blurs affect K-means clustering of trabecular bone ROIs based on their texture features.ResultsThe average CCCs (against the 0 cm reference) for GLCM and GLRM features were ~0.7 at 9 cm. At 18 cm, the average CCCs were reduced to ~0.17 for GLCM and ~0.26 for GLRM. The non-stationary blurs are incorporated in radiomic features of cancellous bone, leading to inconsistencies in clustering of trabecular ROIs between different radial locations: an intersection-over-union overlap of corresponding (most similar) clusters between 0 cm and 9 cm shift was >70%, but dropped to <60% for the majority of corresponding clusters between 0 cm and 18 cm shift.ConclusionNon-stationary CT system blurs reduce inter-scan reproducibility of texture features of trabecular bone in UHR CT, especially for locations <15 cm from the isocenter. Radiomic models of bone quality derived from UHR CT measurements at isocenter might need to be revised before application in peripheral body sites such as the hips.