Topical rapamycin inhibits tuberous sclerosis tumor growth in a nude mouse model.
Topical rapamycin inhibits tuberous sclerosis tumor growth in a nude mouse model.
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DOI：
10.1186/1471-5945-8-1
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发表时间：
2008-01-28
期刊：
影响因子：
--
通讯作者：
Dabora SL
中科院分区：
文献类型：
--
作者：
Rauktys A;Lee N;Lee L;Dabora SL
Skin manifestations of Tuberous Sclerosis Complex (TSC) cause significant morbidity. The molecular mechanism underlying TSC is understood and there is evidence that systemic treatment with rapamycin or other mTOR inhibitors may be a useful approach to targeted therapy for the kidney and brain manifestations. Here we investigate topical rapamycin in a mouse model for TSC-related tumors. 0.4% and 0.8% rapamycin ointments were applied to nude mice bearing subcutaneous, TSC-related tumors. Topical treatments were compared with injected rapamycin and topical vehicle. Rapamycin levels in blood and tumors were measured to assess systemic drug levels in all cohorts. Treatment with topical rapamycin improved survival and reduced tumor growth. Topical rapamycin treatment resulted in systemic drug levels within the known therapeutic range and was not as effective as injected rapamycin. Topical rapamycin inhibits TSC-related tumor growth. These findings could lead to a novel treatment approach for facial angiofibromas and other TSC skin lesions.
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DOI：
10.1164/ajrccm.164.4.2011025
发表时间：
2001-08-15
影响因子：
24.7
作者：
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通讯作者：
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影响因子：
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影响因子：
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作者：
Mathew, T;Kreis, H;Friend, P
通讯作者：
Friend, P