Positive and negative regulation by NK cells in cancer.
Positive and negative regulation by NK cells in cancer.
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DOI：
10.1615/critrevoncog.2014010805
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发表时间：
2014
影响因子：
--
通讯作者：
Murphy WJ
中科院分区：
文献类型：
--
作者：
Sungur CM;Murphy WJ
自1975年首次发现自然杀伤细胞以来，我们对NK生物学的理解已经大大扩展。新的研究已经发现了NK细胞独特亚群上和NK细胞独特亚群的不同水平的免疫调节，这远远超出了NK细胞和靶癌细胞之间简单的受体-配体相互作用。在病毒和肿瘤模型中已经描绘了NK细胞的不同抑制和效应群体。NK细胞与树突细胞、T细胞和B细胞之间的相互作用也显著改变了对癌症的整体免疫应答。为了利用NK细胞亚群的多种功能能力用于癌症免疫治疗，重要的是要了解NK细胞生物学和NK调节机制。
Our understanding of NK biology has expanded immensely since the initial discovery of natural killer cells in 1975. New studies have uncovered various levels of immune regulation both on and by unique subsets of NK cells, which go well beyond simple receptor–ligand interactions between NK cells and target cancer cells. Distinct suppressor and effector populations of NK cells have been delineated in both viral and tumor models. Interactions between NK cells and dendritic cells, T cells, and B cells also dramatically alter the overall immune response to cancer. To exploit the diverse functional abilities of NK cell subsets for cancer immunotherapies, it is important to understand NK cell biology and NK regulator mechanisms.