FACTORS AFFECTING THE GENETIC LOAD IN DROSOPHILA: SYNERGISTIC EPISTASIS AND CORRELATIONS AMONG FITNESS COMPONENTS
FACTORS AFFECTING THE GENETIC LOAD IN DROSOPHILA: SYNERGISTIC EPISTASIS AND CORRELATIONS AMONG FITNESS COMPONENTS
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影响果蝇遗传负荷的因素：协同上位性和适应性成分之间的相关性
DOI：
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
D. Bourguet
中科院分区：
文献类型：
--
作者：
M. Whitlock;D. Bourguet
摘要对影响果蝇遗传负荷的两个因素--协同上位性和性选择进行了研究。一组包含可见隐性突变的五个染色体区域在所有组合中被放在一起，创建了一套完整的32个纯合子系，固定在不同数量的已知突变上。每个品系的适合度有两个衡量标准：生产力(繁殖力和卵到成虫存活率的综合衡量)和竞争性的雄性交配成功。生产力，而不是雄性交配成功，表现出强烈的平均协同上位性模式，即原木适合度随着突变数量的增加而非线性下降。已知协同上位性可以减少突变负荷。这两个适应度成分在特定的突变集合之间显示出一些积极的和一些消极的相互作用。此外，对生产力有有害影响的等位基因也往往会降低雄性交配的成功率。考虑到雄性交配的成功可以在不改变种群平均生产力的情况下影响相对适合度，这些额外的影响将导致有害等位基因的频率和固定率更低，而不会对种群的平均适合度造成更高的成本。通讯编辑：A·卡巴列罗
Abstract Two factors that can affect genetic load, synergistic epistasis and sexual selection, were investigated in Drosophila melanogaster. A set of five chromosomal regions containing visible recessive mutations were put together in all combinations to create a full set of 32 homozygous lines fixed for different numbers of known mutations. Two measures of fitness were made for each line: productivity (a combined measure of fecundity and egg-to-adult survivorship) and competitive male mating success. Productivity, but not male mating success, showed a pattern of strong average synergistic epistasis, such that the log fitness declined nonlinearly with increasing numbers of mutations. Synergistic epistasis is known to reduce the mutation load. Both fitness components show some positive and some negative interactions between specific sets of mutations. Furthermore, alleles with deleterious effects on productivity tend to also diminish male mating success. Given that male mating success can affect relative fitness without changing the mean productivity of a population, these additional effects would lead to lower frequencies and lower fixation rates of deleterious alleles without higher costs to the mean fitness of the population. Corresponding Editor: A. Caballero
上位选择下的穆勒棘轮。
影响因子：
3.3
作者：
Kondrashov,AS
通讯作者：
Kondrashov,AS
影响因子：
3.3
作者：
Sarah P. Otto;David Goldstein
通讯作者：
Sarah P. Otto;David Goldstein
自发突变对数量性状的影响。
影响因子：
3.3
作者：
Houle,D;Hughes,KA;Hoffmaster,DK;Ihara,J;Assimacopoulos,S;Canada,D;Charlesworth,B
通讯作者：
Charlesworth,B