The role of BCL11B in hematological malignancy.
The role of BCL11B in hematological malignancy.
复制标题
BCL11B在血液恶性肿瘤中的作用
DOI：
10.1186/2162-3619-1-22
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发表时间：
2012-08-22
影响因子：
10.9
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Huang X;Du X;Li Y
B细胞白血病/淋巴瘤11B（BCL 11B）基因是BCL家族的成员，其在T细胞的发育、增殖、分化和随后的存活中起关键作用。BCL 11B基因改变与恶性血液病中发生的恶性T细胞转化有关。值得注意的是，BCL 11 B基因负责细胞凋亡过程和细胞增殖的调节。这篇综述总结了目前的数据和知识有关的改变BCL 11B在血液系统恶性肿瘤和它的作用作为一个潜在的目标，针对T细胞恶性肿瘤的治疗。
The B-cell leukemia/lymphoma 11B (BCL11B) gene is a member of the BCL family which plays a crucial role in the development, proliferation, differentiation and subsequent survival of T cells. BCL11B gene alterations are related to malignant T cell transformation that occurs in hematological malignancies. Remarkably, the BCL11B gene is responsible for the regulation of the apoptotic process and cell proliferation. This review summarizes current data and knowledge concerning the alteration of BCL11B in hematological malignancies and its role as a potential target for therapies directed against T cell malignancies.