The Cys282Tyr polymorphism in the HFE gene in Australian Parkinson's disease patients
The Cys282Tyr polymorphism in the HFE gene in Australian Parkinson's disease patients
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DOI：
10.1016/s0304-3940(02)00398-1
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发表时间：
2002-07-19
影响因子：
2.5
通讯作者：
Mellick, GD
中科院分区：
文献类型：
--
作者：
Buchanan, DD;Silburn, PA;Mellick, GD
铁稳态在帕金森病（PD）中改变。HFE蛋白是细胞铁稳态的重要调节因子，该基因内的变异可导致铁过载和称为遗传性血色病的疾病。我们研究了Cys 282 Tyr单核苷酸多态性作为PD的遗传危险因素，在两个不同的和单独收集的澳大利亚PD患者和对照组。在包括438名PD患者和485名对照受试者的联合队列中，我们发现282 Tyr等位基因的优势比为0.61（95%置信区间，Cl = 0.42-0.90，P = 0.011），来自单变量卡方检验和0.59（95% CI = 0.39-0.90，P = 0.014）。这些结果表明，拥有282 Tyr等位基因可能会提供一些保护，防止PD的发展。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Iron homeostasis is altered in Parkinson's disease (PD). The HFE protein is an important regulator of cellular iron homeostasis and variations within this gene can result in iron overload and the disorder known as hereditary haemochromatosis. We studied the Cys282Tyr single nucleotide polymorphism as a genetic risk factor for PD in two distinct and separately collected cohorts of Australian PD patients and controls. In the combined cohort comprising 438 PD patients and 485 control subjects, we revealed an odds ratio for possession of the 282Tyr allele of 0.61 (95% confidence interval, Cl = 0.42-0.90, P = 0.011) from univariate chi-squared and 0.59 (95% Cl = 0.39-0.90, P = 0.014) after logistic regression analyses (correcting for potential confounding factors). These results suggest that possession of the 282Tyr allele may offer some protection against the development of PD. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.