Respiratory epithelial cells orchestrate pulmonary innate immunity.
Respiratory epithelial cells orchestrate pulmonary innate immunity.
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肺部的上皮表面与环境直接接触，并且当气道管和肺泡在通气过程中被拉伸和压缩时，会受到动态物理力的影响。多层先天宿主防御系统的进化已适应了传导气道中的粘液纤毛清除、肺泡表面张力的降低以及近乎无菌的维持。肺部宿主防御的生物物理性质与呼吸道上皮细胞响应和“指导”专业免疫系统保护肺部免受感染和损伤的能力相结合。
The epithelial surfaces of the lungs are in direct contact with the environment and are subjected to dynamic physical forces as airway tubes and alveoli are stretched and compressed during ventilation. Mucociliary clearance in conducting airways, reduction of surface tension in the alveoli, and maintenance of near sterility have been accommodated by the evolution of a multi-tiered innate host-defense system. The biophysical nature of pulmonary host defenses are integrated with the ability of respiratory epithelial cells to respond to and ‘instruct’ the professional immune system to protect the lungs from infection and injury.