A mathematical study for the development of anti-HIV-1 therapies based on the lethal mutagenesis method
A mathematical study for the development of anti-HIV-1 therapies based on the lethal mutagenesis method
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基于致死突变方法开发抗 HIV-1 疗法的数学研究
DOI：
10.1007/s10015-019-00578-2
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发表时间：
2020
影响因子：
0.9
通讯作者：
Kouji Harada
中科院分区：
文献类型：
--
作者：
Kouji Harada ; Tomonari Sumi;Kouji Harada
这项研究试图从数学上揭示基于致命诱变方法的抗hiv治疗相关的困难；确定了两个困难。这种方法的第一个困难是诱变剂的效力必须超过一定的阈值才能治疗HIV-1感染，这可以解释KP-1461试验的明显失败。此外，我们研究了HIV-1的潜伏期对治疗期的影响，并澄清了潜伏期以一种几乎独立于诱变剂功效的方式延长治疗期。这是致死性诱变方法的第二个困难。
This study tried to mathematically unveil the difficulties associated with an anti-HIV therapy based on the lethal mutagenesis method; two difficulties were identified. The first difficulty of this method was that the efficacy of a mutagen must be over a certain threshold to treat HIV-1 infection, which could explain the apparent failure of the KP-1461 trial. Furthermore, we investigated the influence of the latency of HIV-1 on the treatment period and clarified that the latency increases the treatment period in a manner almost independent of the efficacy of a mutagen. This is the second difficulty associated with the lethal mutagenesis method.