Nanotechnology Meets Biology: Peptide-based Methods for the Fabrication of Functional Materials
Nanotechnology Meets Biology: Peptide-based Methods for the Fabrication of Functional Materials
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DOI：
10.1021/jz2016473
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发表时间：
2012-02-02
影响因子：
5.7
通讯作者：
Knecht, Marc R.
中科院分区：
文献类型：
--
作者：
Briggs, Beverly D.;Knecht, Marc R.
大自然利用可持续的方法来创造纳米级的无机材料，用于各种应用。为了实现这样的能力，已经开发了诸如肽和蛋白质的生物分子，其识别并结合材料的不同组成。虽然生物圈中存在一组不同的物质结合序列，但生物组合技术已被用于快速鉴定有助于形成具有技术重要性的新物质的肽。有趣的是，肽在无机表面的结合基序可能控制最终材料的大小、结构、组成、形状和功能。为了推进这些有趣的新的仿生方法，需要对这种生物/非生物界面有一个完整的了解。在这方面，我们强调了纳米粒子的生物功能化的最新进展，其潜在应用范围从催化和储能到等离子体和生物传感。我们特别关注基于肽的表面的物理表征，其中可能嵌入特异性和活性。
Nature exploits sustainable methods for the creation of inorganic materials on the nanoscale for a variety of applications. To achieve such capabilities, biomolecules such as peptides and proteins have been developed that recognize and bind the different compositions of materials. While a diverse set of materials binding sequences are present in the biosphere, biocombinatorial techniques have been used to rapidly identify peptides that facilitate the formation of new materials of technological importance. Interestingly, the binding motif of the peptides at the inorganic surface is likely to control the size, structure, composition, shape, and functionality of the final materials. In order to advance these intriguing new biomimetic approaches, a complete understanding of this biotic/abiotic interface is required. In this Perspective, we highlight recent advances in the biofunctionalization of nanoparticles with potential applications ranging from catalysis and energy storage to plasmonics and biosensing. We specifically focus on the physical characterization of the peptide-based surface from which specificity and activity are likely embedded.