S-nitrosylation and its role in breast cancer angiogenesis and metastasis
S-nitrosylation and its role in breast cancer angiogenesis and metastasis
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DOI：
10.1016/j.niox.2019.03.002
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发表时间：
2019-06-01
影响因子：
3.9
通讯作者：
Sanchez, Fabiola A.
中科院分区：
文献类型：
--
作者：
Ehrenfeld, Pamela;Cordova, Francisco;Sanchez, Fabiola A.
亚硝基化是一氧化氮对半胱氨酸巯基的修饰，是肿瘤发生和转移的重要调控机制。肿瘤细胞中靶点的S-亚硝基化有助于转移调节上皮向间质转化、迁移和侵袭。在肿瘤环境中，S-亚硝基化在内皮中的作用尚未得到解决;然而，有证据指出，内皮蛋白的S-亚硝基化可能调节血管生成、肿瘤细胞与内皮的粘附、肿瘤细胞的内和外渗并有助于转移。
S-nitrosylation, the modification by nitric oxide of free sulfhydtyl groups in cysteines, has become an important regulatory mechanism in carcinogenesis and metastasis. S-nitrosylation of targets in tumor cells contributes to metastasis regulating epithelial to mesenchymal transition, migration and invasion. In the tumor environment, the role of S-nitrosylation in endothelium has not been addressed; however, the evidence points out that S-nitrosylation of endothelial proteins may regulate angiogenesis, adhesion of tumor cells to the endothelium, intra and extravasation of tumor cells and contribute to metastasis.