Prevalence of and risk factors for fatty liver in the general population of Northern Italy: the Bagnacavallo Study
Prevalence of and risk factors for fatty liver in the general population of Northern Italy: the Bagnacavallo Study
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DOI：
10.1186/s12876-018-0906-8
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发表时间：
2018-11-28
影响因子：
2.4
通讯作者：
Stefanini, Giuseppe Francesco
中科院分区：
文献类型：
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作者：
Foschi, Francesco Giuseppe;Bedogni, Giorgio;Stefanini, Giuseppe Francesco
背景：脂肪肝疾病负担的估计需要在普通人群中进行研究。方法：Bagnacavallo研究在2005年10月至2009年3月期间进行。截至2005年1月，Bagnacavallo(意大利拉文纳)30至60岁的所有公民都有资格。肝酶改变定义为丙氨酸氨基转移酶40U/I和/或天冬氨酸氨基转移酶37U/I。结果：692 0名符合条件的受试者中4,033人(58%)同意参加，3 933人(98%)资料完整。后者中393例(10%)有肝酶改变，3540例无改变。排除乙肝病毒或丙型肝炎病毒感染的受试者后，93%的肝酶改变的受试者和52%的肝酶正常的受试者可以进行肝脏超声检查。脂肪肝、非酒精性脂肪性肝病(NAFLD)和酒精性脂肪肝(AFLD)的患病率分别为0.74(95%可信区间0.70~0.79)和0.35(0.33~0.37)，0.46(0.41~0.51)和0.22(0.21~0.24)，0.28(0.24~0.33)和0.13(0.11~0.14)。酒精摄入与脂肪肝无关，代谢综合征(MS)的所有组成部分都与脂肪肝有关。所有潜在的危险因素都与正常肝脏的几率低于非酒精性脂肪肝有关，但无法区分非酒精性脂肪肝和非酒精性脂肪肝。结论：2005/9年间，脂肪肝在巴格纳卡瓦洛地区非常普遍，在肝酶改变的人群中更为常见。
Background: The estimation of the burden of disease attributable to fatty liver requires studies performed in the general population.Methods: The Bagnacavallo Study was performed between October 2005 and March 2009. All the citizens of Bagnacavallo (Ravenna, Italy) aged 30 to 60 years as of January 2005 were eligible. Altered liver enzymes were defined as alanine transaminase > 40 U/I and/or aspartate transaminase > 37 U/I.Results: Four thousand and thirty-three (58%) out of 6920 eligible citizens agreed to participate and 3933 (98%) had complete data. 393 (10%) of the latter had altered liver enzymes and 3540 had not. After exclusion of subjects with HBV or HCV infection, liver ultrasonography was available for 93% of subjects with altered liber enzymes and 52% of those with normal liver enzymes. The prevalence of fatty liver, non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD) was 0.74 (95%CI 0.70 to 0.79) vs. 0.35 (0.33 to 0.37), 0.46 (0.41 to 0.51) vs. 0.22 (0.21 to 0.24) and 0.28 (0.24 to 0.33) vs. 0.13 (0.11 to 0.14) in citizens with than in those without altered liver enzymes. Ethanol intake was not associated and all the components of the metabolic syndrome (MS) were associated with fatty liver. All potential risk factors were associated with a lower odds of normal liver vs. NAFLD while they were unable to discriminate AFLD from NAFLD.Conclusions: Fatty liver as a whole was highly prevalent in Bagnacavallo in 2005/9 and was more common among citizens with altered liver enzymes.