Gender-specific differences in the QT interval and the effect of autonomic tone and menstrual cycle in healthy adults
Gender-specific differences in the QT interval and the effect of autonomic tone and menstrual cycle in healthy adults
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DOI：
10.1016/s0002-9149(96)00707-2
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发表时间：
1997-01-15
影响因子：
2.8
通讯作者：
Kadish, AH
中科院分区：
文献类型：
--
作者：
Burke, JH;Ehlert, FA;Kadish, AH
自20世纪20年代Bazett首次描述以来，校正的QT间期的性别差异就已经被注意到了。这种性别差异的机制尚不清楚，这项研究旨在评估自主神经和月经周期对QT间期的潜在影响。研究人群包括23名女性和20名男性的健康志愿者样本。在月经周期的月经期、卵泡期和黄体期，进行静息状态和双自主神经阻断(阿托品和心得安)后的十二导联心电图测定。男性在三次不同的访问中作为对照进行了研究。女性基线校正QT间期较男性明显延长(421+/-16ms比414+/-15ms：P
Gender differences in the corrected QT interval have been noted since Bazett's initial description during the 1920s. The mechanism of this gender difference is unknown, and this study was undertaken to evaluate potential autonomic and menstrual cycle effects on the QT interval. The study population consisted of a healthy volunteer sample of 23 women and 20 men. Twelve-lead electrocardiographic determinations were made at rest and following double autonomic blockade (with atropine and propranolol) during the menstrual, follicular, and luteal phases of the menstrual cycle. Men were studied during 3 separate visits as controls. The corrected QT interval at baseline tended to be longer in women than men (421 +/- 16 ms vs 414 +/- 15 ms: p