Freezing of gait and white matter changes: a tract-based spatial statistics study.
Freezing of gait and white matter changes: a tract-based spatial statistics study.
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DOI：
10.1186/s40734-014-0011-2
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Hanakawa T
中科院分区：
文献类型：
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作者：
Iseki K;Fukuyama H;Oishi N;Tomimoto H;Otsuka Y;Nankaku M;Benninger D;Hallett M;Hanakawa T
我们假设白色物质的完整性可能与年龄相关的白色物质变化中步态冻结的严重程度有关。招募了20名在脑室周围和深部白色物质中表现出过度高信号的受试者。受试者接受了步态冻结问卷、计算机步态分析和扩散张量磁共振成像。计算轴向、径向和平均扩散率以及分数各向异性的图像作为白色物质完整性的指数，并使用基于轨迹的空间统计进行分析。在整个白色物质结构上平均的各向异性分数、平均值、轴向和径向扩散率均与步态冻结问卷评分显著相关。在区域上，在左侧运动前皮质、右侧胼胝体和左侧大脑脚下方的左侧上级纵束中，步态冻结问卷评分与各向异性分数之间存在负相关。冻结步态问卷的分数呈正相关，平均扩散率在左侧放射冠和右侧胼胝体，并与轴向和径向扩散率在左侧放射冠。这些神经束（胼胝体除外）中的白色物质完整性与认知或其他步态指标无关，支持这些异常对步态冻结的特异性。不同的病理损害涉及由大脑皮层、基底节和脑干组成的神经回路，表明步态冻结具有多因素的性质。
We hypothesized that the integrity of white matter might be related to the severity of freezing of gait in age-related white matter changes. Twenty subjects exhibiting excessive hyperintensities in the periventricular and deep white matter were recruited. The subjects underwent the Freezing of Gait Questionnaire, computerized gait analyses, and diffusion tensor magnetic resonance imaging. Images of axial, radial and mean diffusivity, and fractional anisotropy were calculated as indices of white matter integrity and analyzed with tract-based spatial statistics. The fractional anisotropy, mean, axial and radial diffusivity averaged across the whole white matter structure were all significantly correlated with Freezing of Gait Questionnaire scores. Regionally, a negative correlation between Freezing of Gait Questionnaire scores and fractional anisotropy was found in the left superior longitudinal fasciculus beneath the left premotor cortex, right corpus callosum, and left cerebral peduncle. The scores of the Freezing of Gait Questionnaire were positively correlated with mean diffusivity in the left corona radiata and right corpus callosum, and with both axial and radial diffusivity in the left corona radiata. The white matter integrity in these tracts (except the corpus callosum) showed no correlation with cognitive or other gait measures, supporting the specificity of those abnormalities to freezing of gait. Divergent pathological lesions involved neural circuits composed of the cerebral cortex, basal ganglia and brainstem, suggesting that freezing of gait has a multifactorial nature.