Cell biology in neuroscience: the interplay between Hebbian and homeostatic synaptic plasticity.

Cell biology in neuroscience: the interplay between Hebbian and homeostatic synaptic plasticity.
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神经科学中的细胞生物学:Hebbian和稳态突触可塑性之间的相互作用。

DOI:
10.1083/jcb.201306030
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发表时间:
2013-10-28
期刊:
The Journal of cell biology
影响因子:
--
通讯作者:
Goda Y
Goda Y
中科院分区:
其他
文献类型:
--
作者:
Vitureira N;Goda Y

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突触可塑性是突触信号传导功效的变化,是突触通信的关键特性,对许多脑功能至关重要。赫布形式的持久突触可塑性-长时程增强(LTP)和长时程抑制(LTD)-已经得到了很好的研究,并被认为是特定类型记忆的细胞基础。最近,稳态突触可塑性,突触强度变化的补偿形式,作为抵消LTP和LTD所带来的变化,以帮助稳定神经元网络活动的细胞机制引起了人们的注意。关于这两种可塑性的细胞机制和分子参与者的新发现揭示了它们在单个神经元中的相互作用。
Synaptic plasticity, a change in the efficacy of synaptic signaling, is a key property of synaptic communication that is vital to many brain functions. Hebbian forms of long-lasting synaptic plasticity—long-term potentiation (LTP) and long-term depression (LTD)—have been well studied and are considered to be the cellular basis for particular types of memory. Recently, homeostatic synaptic plasticity, a compensatory form of synaptic strength change, has attracted attention as a cellular mechanism that counteracts changes brought about by LTP and LTD to help stabilize neuronal network activity. New findings on the cellular mechanisms and molecular players of the two forms of plasticity are uncovering the interplay between them in individual neurons.
DOI: 10.1113/jphysiol.1973.sp010273
发表时间: 1973-01-01
影响因子: 5.5
作者:
BLISS, TVP;LOMO, T
通讯作者: LOMO, T
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