Modulation of cyclooxygenase-2 expression by APC in HT-29 human colorectal carcinoma cells.
Modulation of cyclooxygenase-2 expression by APC in HT-29 human colorectal carcinoma cells.
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APC 在 HT-29 人结直肠癌细胞中调节环氧合酶-2 表达。
DOI：
10.1007/978-1-4615-0193-0_21
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发表时间：
2002
影响因子：
--
通讯作者：
Eling,ThomasE
中科院分区：
文献类型：
--
作者：
Hsi,LindaC;Angerman-Stewart,Julie;Eling,ThomasE
环氧合酶（COX）是花生四烯酸代谢的关键酶，可催化花生四烯酸转化为前列腺素H2，后者是前列腺素和凝血素的前体。COX酶存在两种同工异构体。COX-1在组织中组成性表达，COX-2在APC功能丧失后引起炎症反应失调。
Cyclooxygenase (COX) is the key enzyme in arachidonate metabolism and catalyzes the conversion of arachidonic acid to prostaglandin H2, the precursor for prostaglandins and thromboxanes’. Two isoforms of the COX enzyme exist. COX-1 is constitutively expressed in tissues while COX-2 is induced in inflammatory reactions’ dysregulated after loss of APC function.