Repeat Infection With Chlamydia and Gonorrhea Among Females: A Systematic Review of the Literature
Repeat Infection With Chlamydia and Gonorrhea Among Females: A Systematic Review of the Literature
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DOI：
10.1097/olq.0b013e3181a2a933
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发表时间：
2009-08-01
影响因子：
3.1
通讯作者：
Bauer, Heidi M.
中科院分区：
文献类型：
--
作者：
Hosenfeld, Christina B.;Workowski, Kimberly A.;Bauer, Heidi M.
确定衣原体和淋病再感染的程度对于告知与治疗后重新检测相关的循证临床实践指南至关重要。PubMed用于识别过去30年发表的同行评议的英语研究，这些研究估计了接受衣原体或淋病治疗的女性的再感染率。这项分析包括在美国和其他工业化国家进行的原始研究，这些研究报告了女性衣原体或淋病再感染的数据。根据研究设计将研究分为3层。再感染率与微生物、螺种、设计、随访时间和种群特征有关。在纳入的47项研究中。16例为主动队列（1级），15例为被动队列（2级）。和16项疾病登记（第3层）研究。女性再次感染衣原体的总体中位比例为13.9%（n = 38项研究）。12个月内的衣原体再感染模型显示，8至10个月的峰值率为19%至20%。女性再次感染淋病的总体中位比例为11.7%（n = 17项研究）。年龄越小，衣原体和淋病再感染率越高。女性衣原体和淋病的再感染率高。沿着实际考虑，需要在初次感染治疗后3至6个月进行复检。进一步的研究应调查有效的干预措施，以减少再感染和增加重新检测。
Determining the magnitude of chlamydia and gonorrhea reinfection is critical to inform evidence-based clinical practice guidelines related to retesting after treatment. PubMed was used to identify peer-reviewed English language studies published in the past 30 years that estimated reinfection rates among females treated for chlamydia or gonorrhea. Included in this analysis were original studies conducted in the United States and other industrialized countries that reported data on chlamydia or gonorrhea reinfection in females. Studies were stratified into 3 tiers based on study design. Reinfection rates were examined in relation to the organism, stud), design, length of follow-Lip, and population characteristics. Of the 47 studies included. 16 were active cohort (Tier 1), 15 passive cohort (Tier 2). and 16 disease registry (Tier 3) studies. The overall median proportion of females reinfected with chlamydia was 13.9% (n = 38 studies). Modeled chlamydia reinfection within 12 months demonstrated peak rates of 19% to 20% at 8 to 10 months. The overall median proportion of females reinfected with gonorrhea was 11.7% (n = 17 studies). Younger age was associated with higher rates of both chlamydia and gonorrhea reinfection. High rates of reinfection with chlamydia and gonorrhea among females. along with practical considerations, warrant retesting 3 to 6 months after treatment of the initial infection. Further research should investigate effective interventions to reduce reinfection and to increase retesting.