Beyond the Reward Pathway: Coding Reward Magnitude and Error in the Rat Subthalamic Nucleus
Beyond the Reward Pathway: Coding Reward Magnitude and Error in the Rat Subthalamic Nucleus
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DOI：
10.1152/jn.91009.2008
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发表时间：
2009-10-01
影响因子：
2.5
通讯作者：
Baunez, Christelle
中科院分区：
文献类型：
--
作者：
Lardeux, Sylvie;Pernaud, Remy;Baunez, Christelle
杨文伟，王晓，王晓伟，王晓伟.奖赏通路之外：大鼠丘脑底核的奖赏幅度和错误编码。J Neurophysiol 102：2526-2537，2009.首次发表于2009年8月26日; doi：10.1152/jn.91009.2008。最近的研究表明，丘脑底核（subthalamic nucleus，简称丘脑底核）的损伤会根据奖赏的性质或对奖赏的偏好，对食物、可卡因和酒精的动机产生不同的影响，因此丘脑底核可能会根据奖赏的价值来编码奖赏。在这里，我们研究了在两种可能性（4或32%蔗糖溶液）之间的预测奖励的预期期间，底丘脑神经元的放电是如何调制的。神经元对预测线索和奖励传递做出反应的放电模式表明，神经元可以分为对一种奖励做出特异性反应的亚群，对另一种奖励做出较少反应或不做出反应。此外，一些神经元（“oops”神经元）专门编码错误，因为它们只在错误试验期间做出反应。这些结果表明，大脑皮层在确定奖励的价值方面起着关键作用，并且似乎根据奖励的大小对该价值进行了不同的编码。这些数据突出了大脑奖励回路中的神经元的重要性。
Lardeux S, Pernaud R, Paleressompoulle D, Baunex C. Beyond the reward pathway: coding reward magnitude and error in the rat subthalamic nucleus. J Neurophysiol 102: 2526-2537, 2009. First published August 26, 2009; doi:10.1152/jn.91009.2008. It was recently shown that subthalamic nucleus (STN) lesions affect motivation for food, cocaine, and alcohol, differentially, according to either the nature of the reward or the preference for it. The STN may thus code a reward according to its value. Here, we investigated how the firing of subthalamic neurons is modulated during expectation of a predicted reward between two possibilities (4 or 32% sucrose solution). The firing pattern of neurons responding to predictive cues and to reward delivery indicates that STN neurons can be divided into subpopulations responding specifically to one reward and less or giving no response to the other. In addition, some neurons ("oops" neurons) specifically encode errors as they respond only during error trials. These results reveal that the STN plays a critical role in ascertaining the value of the reward and seems to encode that value differently depending on the magnitude of the reward. These data highlight the importance of the STN in the reward circuitry of the brain.