Proprotein Convertase Subtilisin/Kexin Type 9 Is Associated with Degenerating Adipocytes in Abdominal Aortic Aneurysm
Proprotein Convertase Subtilisin/Kexin Type 9 Is Associated with Degenerating Adipocytes in Abdominal Aortic Aneurysm
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DOI：
10.5650/jos.ess18131
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发表时间：
2018-10-01
影响因子：
1.5
通讯作者：
Urano, Tetsumei
中科院分区：
文献类型：
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作者：
Tanaka, Hiroki;Inuzuka, Kazunori;Urano, Tetsumei
腹主动脉瘤（AAA）是老年人的常见病。最近，前蛋白转化酶枯草杆菌蛋白酶/kexin 9型（PCSK 9）抑制剂已被指示为用于治疗心血管疾病的有用的治疗工具。本研究的目的是阐明PCSK 9在AAA发病机制中的作用。我们采用荧光免疫组织化学方法检测了24例AAA患者主动脉组织中PCSK 9的表达。组织学检查显示，在AAA样本中，动脉瘤外膜区域的PCSK 9表达减少。在同一区域，CD 36表达增加。我们假设CD 36表达可能上调脂肪酸转运到细胞（如脂肪细胞）中，随后导致主动脉壁外膜降解，导致AAA发生。
Abdominal aortic aneurysm (AAA) is a common disease among the elderly. Recently, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have been indicated as useful therapeutic tools for the treatment of cardiovascular diseases. The aim of this study was to elucidate the role of PCSK9 in the pathogenesis of AAA. We used fluorescence immunohistochemistry to assess the expression of PCSK9 in aortic tissues resected from 24 patients with AAA. Histological examination showed that PCSK9 expression in the adventitia region of the aneurysms was decreased in AAA samples. In the same region, the expression of CD36 increased. We hypothesized that CD36 expression might upregulate the transport of fatty acids into cells such as the adipocytes, and subsequently cause degradation of the adventitia in the aortic wall, contributing to AAA development.