MRI T2 lesion burden in multiple sclerosis - A plateauing relationship with clinical disability
MRI T2 lesion burden in multiple sclerosis - A plateauing relationship with clinical disability
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DOI：
10.1212/01.wnl.0000210506.00078.5c
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发表时间：
2006-05-09
期刊：
影响因子：
9.9
通讯作者：
Filippi, M
中科院分区：
文献类型：
--
作者：
Li, DKB;Held, U;Filippi, M
背景：以前的研究表明，多发性硬化（MS）MRI病变与临床残疾之间只有适度的相关性。目的：研究MRI扫描定量测量的质子密度/T2加权（T2）疾病负担（BOD）与包括残疾在内的临床决定因素之间的关系。研究方法：使用Sylvia Lawry多发性硬化研究中心（SLCMSR）数据库，作者研究了来自11项随机对照试验的1，312名安慰剂MS患者的汇总子样本的基线T2 BOD数据。单变量比较指导多元回归模型的发展，包括最重要的临床预测因子。结果如下：T2 BOD与疾病发作时的年龄、疾病持续时间、疾病病程、残疾（通过扩展残疾状态量表[EDSS]测量）、复发率、某些表现症状和钆增强之间存在显著相关性（尽管弱至中度）。在多元回归分析中持续存在的一个意想不到但关键的发现是，EDSS值高于4.5时，T2 BOD与残疾之间存在平稳关系。结论：这项研究证实了临床表现和T2疾病负担（BOD）之间的有限相关性，但揭示了T2 BOD和残疾之间的重要平台关系。
Background: Previous studies have shown only modest correlation between multiple sclerosis (MS) lesions on MRI and clinical disability. Objective: To investigate the relationship between proton density/T2-weighted (T2) burden of disease (BOD) quantitatively measured on MRI scans and clinical determinants including disability. Methods: Using the Sylvia Lawry Centre for Multiple Sclerosis Research (SLCMSR) database, the authors studied baseline T2 BOD data from a pooled subsample of 1,312 placebo MS patients from 11 randomized controlled trials. Univariate comparisons guided development of multiple regression models incorporating the most important clinical predictors. Results: Significant, although weak to moderate, correlations were found between T2 BOD and age at disease onset, disease duration, disease course, disability (as measured by the Expanded Disability Status Scale [EDSS]), relapse rate, certain presenting symptoms, and gadolinium enhancement. An unexpected but key finding that persisted in the multiple regression analyses was a plateauing relationship between T2 BOD and disability for EDSS values above 4.5. Conclusions: This study confirmed the limited correlation between clinical manifestations and T2 burden of disease (BOD) but revealed an important plateauing relationship between T2 BOD and disability.