Perceived psychologic stress and colorectal cancer mortality: Findings from the Japan collaborative cohort study
Perceived psychologic stress and colorectal cancer mortality: Findings from the Japan collaborative cohort study
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DOI：
10.1097/01.psy.0000151742.43774.6d
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发表时间：
2005-01-01
影响因子：
3.3
通讯作者：
Tamakoshi, A
中科院分区：
文献类型：
--
作者：
Kojima, M;Wakai, K;Tamakoshi, A
目的：本研究的目的是在一项前瞻性的大规模研究中，探讨感知心理压力与结直肠癌死亡率之间的关系。方法：1988年至1990年，32,153名男性和45,854名女性年龄在40至79岁之间。参与者完成了一份自我管理的问卷调查，涉及人口统计学，生活方式和心理社会特征。随后对受试者的死亡率进行了随访，直至1999年底。知觉心理压力的评估使用的问题是“你觉得压力在你的日常生活？4种可能的反应，从“很少或没有”（1）到“极端”（4），被分为低（1或2）或高（3或4）压力。使用考克斯比例风险模型估计结肠癌和直肠癌的相对危险度（RR）及其95%置信区间（CI）。结果如下：在随访期间（平均9.6年），研究组中确认了193例结肠癌死亡（96例男性和97例女性）和127例直肠癌死亡（88例男性和39例女性）。与那些报告低压力的女性相比，报告高压力的女性结肠癌死亡率的风险高1.64倍（多变量调整的RR，1.64; 95%CI，1.01-2.66）。感知压力与女性直肠癌或男性结肠癌和直肠癌死亡率之间没有显着关联。结论：心理压力与女性结肠癌死亡率的增加有微弱的相关性。在男性中没有发现正相关或负相关。需要进一步的研究来证实我们的结果。
Objective: The purpose of this research was to examine the relationship between perceived psychologic stress and colorectal cancer mortality in a prospective large-scale study. Methods: Between the years 1988 and 1990, 32,153 men and 45,854 women aged 40 to 79 years were enrolled. Participants completed a self-administered questionnaire that addressed demographic, lifestyle, and psychosocial characteristics. Subjects were subsequently followed for mortality until the end of 1999. Perceived psychologic stress was assessed using the question "Do you feel stress during your daily life?" The 4 possible responses, ranging from "little or none" (1) to "extreme" (4), were dichotomized as low (I or 2) or high (3 or 4) stress. Relative risks (RRs) with 95% confidence intervals (CIs) for colon and rectal cancer according to the perceived level of stress were estimated using Cox's proportional hazard model. Results: During the follow-up period (average, 9.6 years), 193 colon cancer deaths (96 men and 97 women) and 127 rectal cancer deaths (88 men and 39 women) were confirmed within the study group. Women who reported high stress had a 1.64-fold higher risk of colon cancer mortality (multivariate-adjusted RR, 1.64; 95% CI, 1.01-2.66) compared with those reporting low stress. There was no significant association between perceived stress and female rectal cancer or male colon and rectal cancer mortality. Conclusions: Perceived psychologic stress was weakly associated with increased mortality from colon cancer in women. No positive or inverse association was found in men. Further studies are needed to confirm our results.