Determination of fluoroquinolone antibiotics in wastewater effluents by liquid chromatography-mass spectrometry and fluorescence detection
Determination of fluoroquinolone antibiotics in wastewater effluents by liquid chromatography-mass spectrometry and fluorescence detection
复制标题
DOI：
10.1016/j.chemosphere.2004.08.097
复制
发表时间：
2005-02-01
期刊：
影响因子：
8.8
通讯作者：
Giesy, JP
中科院分区：
文献类型：
--
作者：
Nakata, H;Kannan, K;Giesy, JP
采用混合相阳离子交换圆盘固相萃取-液相色谱-质谱联用技术（LC-MS）和液相色谱-荧光检测技术（LC-FLD），对美国和加拿大的污水和地表河/湖沃茨中喹诺酮类抗生素（QAs）进行了研究。在密歇根州东兰辛的污水处理厂（WWP）的二级和最终流出物中检测到氧氟沙星（OFL），浓度分别为204和100 ng/l。质量流量计算，通过将最终流出物中的OFL浓度乘以污水处理厂的平均进水体积来估算。结果表明，OFL向河流的排放量为4.8g/d。在这项研究中测量的废水流出物中的OFL浓度与在几个欧洲国家观察到的浓度相当或更低。在本研究分析的河流和湖泊沃茨中未检测到QA。这可能是由于稀释效应和较高的检测限。OFL浓度比环境细菌的EC_（50）浓度低1 -2个数量级。然而，污水处理厂的污水污泥中其他QA浓度较高可能会导致累积效应。考虑到污水污泥被用作肥料。土壤中的生物可能会更多地接触到这些抗生素。有必要对污水处理厂的污水以及水产养殖设施和畜牧场附近的沉积物/土壤中的QA进行监测研究，以评估这些化合物的环境分布和风险。(C)2004爱思唯尔有限公司保留所有权利。
The occurrence of quinolone antibiotics (QAs) was investigated in wastewater effluents and surface river/lake waters in the US and Canada by using solid-phase extraction with mixed phase cation exchange disk cartridge and liquid chromatography-mass spectrometry (LC-MS) and liquid chromatography fluorescence detection (LC-FLD). Ofloxacin (OFL) was detected in secondary and final effluents of a wastewater treatment plant (WWP) in East Lansing, Michigan, at concentrations of 204 and 100 ng/l, respectively. The mass flow calculation, estimated by multiplying the OFL concentration in the final effluent by the average influent volume of the WWTP. showed that the discharge of OFL to the river was 4.8g/day. The OFL concentrations in wastewater effluents measured in this studs, are comparable to or less than those observed in several European countries. QAs were not detected in river and lake waters analsyed in this studs,. which may due to dilution effects and to the higher detection limits. relative to those reported previously OFL concentrations were approximate to1-2 orders of magnitude lower than the EC50 concentrations for environmental bacterium. However, greater concentrations of other QAs in sewage sludge from WWTPs may result in cumulative effects. Considering that the sewage sludge is applied to the land as fertilizers. soil-dwelling organisms could experience greater exposures to such antibiotics. Monitoring studies of QAs in sewage from WWTPs and in sediment/soil near aquaculture facilities and livestock farms will be necessary for the evaluation of the environmental distribution and risk of these compounds. (C) 2004 Elsevier Ltd. All rights reserved.