LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development.
LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development.
复制标题
DOI：
10.1016/j.neuron.2009.07.031
复制
发表时间：
2009-09-10
期刊：
影响因子：
16.2
通讯作者：
Ginty, David D.
中科院分区：
文献类型：
--
作者：
Mandai, Kenji;Guo, Ting;Hillaire, Coryse St.;Meabon, James S.;Kanning, Kevin C.;Bothwell, Mark;Ginty, David D.
进行全基因组筛选以鉴定介导轴突生长、引导和靶向区域体感神经元神经支配的跨膜蛋白。其中一个基因Linx（别名Islr 2）编码富含亮氨酸的重复序列和免疫球蛋白（LIG）家族蛋白，在发育中的感觉和运动神经元中表达。Linx和其他LIG家族成员的结构域和基因组结构表明，它们在进化上与Trk受体酪氨酸激酶（RTK）相关。包括Linx在内的几种LIGs在体感和运动神经元的亚群中表达，并选择与TrkA和Ret RTK相互作用的成员。此外，在Linx中携带无效突变的小鼠中的轴突投射缺陷类似于缺乏Ngf、TrkA和Ret的小鼠中的轴突投射缺陷。此外，Linx分别调节培养的感觉和运动神经元中NGF-TrkA和GDNF-GFR α1/Ret介导的轴突延伸。这些发现表明，LIGs与RTK物理相互作用，并调节它们的活性以控制轴突延伸、引导和分支。
Genome-wide screens were performed to identify transmembrane proteins that mediate axonal growth, guidance and target field innervation of somatosensory neurons. One gene, Linx (alias Islr2), encoding a leucine-rich repeat and immunoglobulin (LIG) family protein, is expressed in a subset of developing sensory and motor neurons. Domain and genomic structures of Linx and other LIG family members suggest that they are evolutionarily related to Trk receptor tyrosine kinases (RTKs). Several LIGs, including Linx are expressed in subsets of somatosensory and motor neurons and select members interact with TrkA and Ret RTKs. Moreover, axonal projection defects in mice harboring a null mutation in Linx resemble those in mice lacking Ngf, TrkA and Ret. In addition, Linx modulates NGF–TrkA- and GDNF–GFRα1/Ret-mediated axonal extension in cultured sensory and motor neurons, respectively. These findings show that LIGs physically interact with RTKs and modulate their activities to control axonal extension, guidance and branching.
登录
查看更多内容
影响因子：
25
作者：
Kim, Seho;Burette, Alain;Kim, Eunjoon
通讯作者：
Kim, Eunjoon
影响因子：
11.4
作者：
Gur, G;Rubin, C;Yarden, Y
通讯作者：
Yarden, Y
影响因子：
5.3
作者：
Ledda, Fernanda;Bieraugel, Oliver;Paratcha, Gustavo
通讯作者：
Paratcha, Gustavo
DOI：
10.1073/pnas.0700901104
发表时间：
2007-09-04
影响因子：
11.1
作者：
Inoue, Haruhisa;Lin, Ling;Isacson, Ole
通讯作者：
Isacson, Ole
影响因子：
16.2
作者：
Huber, AB;Kania, A;Kolodkin, AL
通讯作者：
Kolodkin, AL