Serum amyloid A-positive hepatocellular neoplasms in the resected livers from 3 patients with alcoholic cirrhosis.
Serum amyloid A-positive hepatocellular neoplasms in the resected livers from 3 patients with alcoholic cirrhosis.
复制标题
3 名酒精性肝硬化患者的切除肝脏中血清淀粉样蛋白 A 阳性肝细胞肿瘤。
DOI：
10.14670/hh-28.1499
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发表时间：
2013
影响因子：
2
通讯作者：
Y. Nakanuma
中科院分区：
文献类型：
--
作者：
M. Sasaki;F. Kondo;Yoshiyuki Sawai;Y. Imai;S. Kadowaki;K. Sano;T. Fukusato;O. Matsui;Y. Nakanuma
在3例酒精性肝硬化患者（2男1女）的切除肝脏中发现12个肝细胞结节。影像学检查提示结节内血供丰富，可能为肝细胞癌。5个结节（直径4-31 mm）为血清淀粉样蛋白A阳性肝细胞肿瘤，与炎性肝细胞腺瘤具有相同的特征。其余7个结节（5-8 mm）为局灶性结节增生样结节，显示局灶性或无血清淀粉样蛋白A免疫染色。血清淀粉样蛋白A阳性的肝细胞肿瘤表现为不同程度的细胞密度增加、炎性浸润、肝窦扩张和小管反应。这些组织学特征在局灶性结节增生样结节中往往不那么广泛。4例血清淀粉样蛋白A阳性的肝细胞肿瘤中有3例在磁共振（MR）成像上表现为肝胆相轻度低信号，并伴有钆乙氧基苄基二乙烯三胺五乙酸（Gd-EOB-DTPA）增强。相反，3个局灶性结节增生样结节在肝胆期呈等信号。这项研究进一步证实了酒精性肝硬化中血清淀粉样蛋白A阳性肝细胞肿瘤的特征，这些肿瘤与炎性肝细胞腺瘤具有相同的特征。血清淀粉样蛋白A阳性肝细胞肿瘤有时与局灶性结节增生样结节共存，在Gd-EOB增强MR成像上可能表现出不同的表现。
Twelve hepatocellular nodules were characterized in the resected livers from 3 patients (2 men and a woman) with alcoholic cirrhosis. Imaging techniques suggested that the nodules were hypervascular and may be hepatocellular carcinoma. Five nodules (4-31 mm in diameter) were serum amyloid A-positive hepatocellular neoplasm, which shares features with inflammatory hepatocellular adenoma. The remaining 7 nodules (5-8 mm) were focal nodular hyperplasia-like nodules showing focal or no immunostaining for serum amyloid A. The serum amyloid A-positive hepatocellular neoplasms showed increased cellular density, inflammatory infiltrate, sinusoidal dilatation, and ductular reaction to various degrees. These histologic features tended to be less extensive in focal nodular hyperplasia-like nodules. Three of 4 serum amyloid A-positive hepatocellular neoplasms showed slight hypointensity in the hepatobiliary phase on the magnetic resonance (MR) imaging with gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA) enhancement. In contrast, 3 focal nodular hyperplasia-like nodules showed iso-intensity in the hepatobiliary phase. This study further confirms characteristics of serum amyloid A-positive hepatocellular neoplasm arising in alcoholic cirrhosis that share features with inflammatory hepatocellular adenomas. Serum amyloid A-positive hepatocellular neoplasms sometimes co-exist with focal nodular hyperplasia-like nodules and may show different findings on Gd-EOB-enhanced MR imaging.
影响因子：
19.7
作者：
Kitao, Azusa;Zen, Yoh;Nakanuma, Yasuni
通讯作者：
Nakanuma, Yasuni
影响因子：
6
作者：
Sasaki, Motoko;Ikeda, Hiroko;Nakanuma, Yasuni
通讯作者：
Nakanuma, Yasuni