Cleveland clinic CorAide blood pump circulatory support without anticoagulation.
Cleveland clinic CorAide blood pump circulatory support without anticoagulation.
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克利夫兰诊所 CorAide 血泵循环支持，无需抗凝。
DOI：
10.1097/00002480-200205000-00009
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Fukamachi,Kiyotaka
中科院分区：
文献类型：
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作者：
Ochiai,Yoshie;Golding,LeonardAR;Massiello,AlexL;Medvedev,AlexanderL;Horvath,DavidJ;Gerhart,ReneeL;Chen,Ji-Feng;Krogulecki,AlexandraY;Takagaki,Masami;Doi,Kazuyoshi;Howard,MichaelW;Fukamachi,Kiyotaka
Cleveland Clinic CorAide左心室辅助系统由一个永久植入式离心泵组成，其中旋转组件完全悬浮且不接触。进行了一系列慢性动物体内研究，以评价不使用抗凝治疗的CorAide循环支持的生物学效应。将CorAide泵植入6头小牛（5头小牛植入21 - 32天，1头小牛植入95天）。前5头小牛在术后早期（2-7天）静脉注射肝素。然后停止肝素给药，在实验期间不使用其他抗凝药物。最后一头小牛在手术期间未接受任何抗凝剂，但肝素推注剂量（200 U/kg）除外。所有6头小牛的血流动力学稳定，平均泵流量为5.6±1.2 L/min，平均动脉压为100±4 mm Hg。所有6头小牛的血泵表面均无血栓。尸检的显著发现仅限于1例肾梗死。未发生机械故障、出血或器械感染。CorAide泵可以在最低限度或无抗凝治疗的情况下安全运行。
The Cleveland Clinic CorAide left ventricular assist system consists of a permanently implantable centrifugal pump in which the rotating assembly is completely suspended and noncontacting. A series of chronic animal in vivo studies were conducted to evaluate the biologic effects of CorAide circulatory support without the use of anticoagulation therapy. The CorAide pump was implanted in six calves (five calves for 21 to 32 days and one calf for 95 days). The first five calves received intravenous heparin during the early postoperative periods (2–7 days). Heparin administration was then discontinued and no other anticoagulant drugs were used for the duration of the experiments. The last calf did not receive any anticoagulant except for a bolus dose of heparin (200 U/kg) during surgery. Hemodynamics were stable in all six calves, with a mean pump flow of 5.6±1.2 L/min and mean arterial pressure of 100±4 mm Hg. The blood pump surfaces were clean of thrombus in all six calves. Significant findings at autopsy were limited to one case of renal infarction. There was no incidence of mechanical failure, bleeding, or device infection. The CorAide pump can be safely run with minimal or no anticoagulant therapy.