Differential metabolic profile associated with the condition of normoalbuminuria in the hypertensive population
Differential metabolic profile associated with the condition of normoalbuminuria in the hypertensive population
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DOI：
10.1016/j.nefro.2019.10.007
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发表时间：
2020-07-01
期刊：
影响因子：
2.6
通讯作者：
Alvarez-Llamas, Gloria
中科院分区：
文献类型：
--
作者：
Santiago-Hernandez, Aranzazu;Martinez, Paula J.;Alvarez-Llamas, Gloria
背景和目的：白蛋白尿是亚临床器官损害的指标，也是心血管风险和肾脏疾病的标志物。高血压患者中有一定比例的患者尽管长期处于肾素-血管紧张素系统（RAS）抑制状态，但仍会出现蛋白尿。我们以前确定了与蛋白尿的发展相关的尿代谢产物。在这项研究中，我们寻找代谢的改变，反映了不同水平的条件下normoalbuminuria.Patients，材料和方法：尿液从48高血压患者慢性RAS抑制进行了分析。根据白蛋白/肌酐比值（ACR）将其分为3组：正常白蛋白尿（
Background and aim: Albuminuria is an indicator of sub-clinical organ damage and a marker of cardiovascular risk and renal disease. A percentage of hypertensive patients develop albuminuria despite being under chronic suppression of the renin-angiotensin system (RAS). We previously identified urinary metabolites associated with the development of albuminuria. In this study, we searched for metabolic alterations which reflect different levels within the condition of normoalbuminuria.Patients, materials and methods: Urine from 48 hypertensive patients under chronic RAS suppression was analysed. They were classified according to the albumin/creatinine ratio (ACR) into 3 groups: Normoalbuminuria (