Time to local recurrence as a predictor of survival in unrecetable gastric cancer patients after radical gastrectomy.
Time to local recurrence as a predictor of survival in unrecetable gastric cancer patients after radical gastrectomy.
复制标题
DOI：
10.18632/oncotarget.19038
复制
发表时间：
2017-10-24
期刊：
影响因子：
--
通讯作者：
Hong W
中科院分区：
文献类型：
--
作者：
Li H;Jin X;Liu P;Hong W
根治性手术后局部复发很常见。然而，影响局部复发后存活的因素仍不清楚。在这项回顾性研究中，我们分析了74例局部复发的胃癌患者的复发时间与复发后生存率的关系。所有患者均接受姑息性放疗加或不加化疗。根据胃切除至局部复发的时间分为两组：早期局部复发组(首次手术后12个月)和晚期局部复发组(首次手术后12个月后局部复发)(LLR，≥)。ELR患者的中位总生存期(OS)为15个月，LLR患者为25个月。单因素和多因素分析显示，局部复发时间与局部复发后OS显著相关(P=0.001)。与LLR患者相比，ELR的风险比为0.442(95%可信区间：0.264-0.741)。这些结果表明，早期局部复发预示着不能切除局部复发的胃癌患者预后较差。
Local recurrence is common after radical surgery. However, the factors that contribute to survival after local recurrence remain unclear. In this retrospective study we analyzed the relationship between time to recurrence and survival after recurrence in 74 patients with locally recurrent gastric cancer. All patients received palliative radiotherapy with or without chemotherapy. The patients were divided into two groups according to the time between gastrectomy and local recurrence: early local recurrence (ELR, < 12 months after primary surgery), and late local recurrence (LLR, ≥12 months after primary surgery). The median overall survival (OS) time was 15 months for patients with ELR and 25 months for LLR patients. Univariate and multivariate analysis revealed that time to local recurrence was significantly associated with OS after local recurrence (P = 0.001). The hazard ratio of ELR compared with LLR patients was 0.442 (95% confidence interval: 0.264-0.741). These results indicate that early local recurrence predicted poor prognosis in gastric cancer patients with unresectable local recurrence.
登录
查看更多内容
DOI：
10.1016/0360-3016(90)90344-j
发表时间：
1990-12-01
影响因子：
7
作者：
LANDRY, J;TEPPER, JE;SULLINGER, J
通讯作者：
SULLINGER, J
影响因子：
3.7
作者：
Gentilini, Oreste;Botteri, Edoardo;Veronesi, Umberto
通讯作者：
Veronesi, Umberto
影响因子：
9
作者：
Hahnloser, D;Nelson, H;Horgan, A
通讯作者：
Horgan, A
影响因子：
2.8
作者：
Huh, Jung Wook;Kim, Chang Hyun;Kim, Young Jin
通讯作者：
Kim, Young Jin
影响因子：
3.9
作者：
Shoup, M;Guillem, JG;Minsky, BD
通讯作者：
Minsky, BD