Blastocyst stage transfer vs cleavage stage embryo transfer.
Blastocyst stage transfer vs cleavage stage embryo transfer.
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DOI：
10.4103/0974-1208.51339
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发表时间：
2009-01
影响因子：
--
通讯作者：
George K
中科院分区：
文献类型：
--
作者：
Mangalraj AM;Muthukumar K;Aleyamma T;Kamath MS;George K
评价囊胚移植与卵裂期胚胎移植在相似队列妇女中的疗效。回顾性分析。大学教学医院。在2005年1月至2006年12月期间接受体外受精/胞浆内精子注射的35岁或以下女性被纳入研究。当在第3天观察到4个或更多个1级胚胎时，进行延长培养直至第5天。这项政策与一组在第3天至少有3个1级胚胎的妇女进行了比较，这些妇女在2002年1月至2004年12月期间接受了卵裂期胚胎移植。评价的主要结局是种植率和临床妊娠率。第1组包括50名接受扩展培养和囊胚移植的妇女。第2组为85例接受乳沟移植的妇女。第1组移植胚胎的种植率显著高于第3天移植胚胎的种植率（40.16%vs11.43%）。囊胚期移植的临床妊娠率也明显高于卵裂期移植（62%比29.76%）。与第3天移植相比，在囊胚期移植所需的胚胎显著减少（2.54 vs 3.45）。在选定的情况下，可以进行胚胎较少的囊胚移植，植入率和临床妊娠率较高。这一政策可能会导致减少高阶妊娠的发生率。
To evaluate the efficacy of blastocyst transfer in comparison with cleavage stage embryo in a similar cohort of women. Retrospective analysis. University teaching hospital. Women aged 35 or less undergoing in vitro fertilization/intracytoplasmic sperm injection between January 2005 and December 2006 were included in the study. When four or more grade 1 embryos were observed on day 3, extended culture till day 5 was undertaken. This policy was compared with a cohort of women who had at least three grade 1 embryos on day 3 and who had undergone a cleavage stage embryo transfer during the time period of January 2002–December 2004. Primary outcome evaluated was implantation rate and clinical pregnancy rate. Group 1 consisted of 50 women who underwent extended culture and blastocyst transfer. Group 2 comprised of 85 women who had cleavage transfer. The implantation rate for embryos transferred in group 1 was significantly higher than that for embryos transferred on day 3 (40.16% vs 11.43%). The clinical pregnancy rate was also significantly better with blastocyst transfer as compared with cleavage stage transfer (62% vs 29.76%). Significantly fewer embryos were required for transfer at the blastocyst stage compared with day 3 transfer (2.54 vs 3.45). In selected cases, blastocyst transfer with fewer embryos can be performed with high implantation and clinical pregnancy rates. This policy could lead to a reduction in the incidence of higher-order pregnancies.