Effect of naltrexone on food intake and body weight in Syrian hamsters depends on metabolic status.
Effect of naltrexone on food intake and body weight in Syrian hamsters depends on metabolic status.
复制标题
纳曲酮对叙利亚仓鼠食物摄入量和体重的影响取决于代谢状态。
DOI：
10.1016/s0031-9384(02)00894-6
复制
发表时间：
2003
影响因子：
2.9
通讯作者：
Corp,EricS
中科院分区：
文献类型：
--
作者：
Jones,JuliE;Corp,EricS
阿片类药物是一个神经肽家族，参与控制食物摄入和调节体重。一般而言，非选择性阿片类拮抗剂在啮齿类动物的多种范例中抑制食物摄入。叙利亚仓鼠可能是一般调查结果的例外。在以前的报告中，我们表明，全身给予阿片类拮抗剂纳洛酮2天，增加体重的雌性叙利亚仓鼠。为了证实这些发现的程度，我们设计了本实验，测试慢性6天输注纳洛酮对自由喂养的雄性仓鼠的食物摄入量、水摄入量和体重的影响。此外，我们还研究了纳洛酮急性给药对自由采食和禁食仓鼠摄食量的影响。我们发现，慢性全身给药纳洛酮导致食物摄入量和体重显着增加。第二，急性给药纳洛酮减少48小时禁食后的食物摄入量，但对自由采食的仓鼠没有影响。在任何实验范例中，水消耗量都没有改变。我们的研究结果表明，当叙利亚仓鼠处于正能量平衡时，叙利亚仓鼠中的阿片类药物回路可能具有抑制食物摄入和体重的作用。巧合的是，阿片类药物可能会在持续禁食后增加食物摄入。
Opioids are a family of neuropeptides involved in the control of food intake and regulation of body weight. In general, nonselective opioid antagonists have inhibited food intake in a variety of paradigms in rodent species. Syrian hamsters may be an exception to the general findings. In a previous report, we showed that systemic administration of an opioid antagonist, naltrexone, for 2 days increased body weight in female Syrian hamsters. To confirm the extent of these finding we designed the present experiment testing the effect of a chronic 6-day infusion of naltrexone on food intake, water intake, and body weight in freely feeding male hamsters. In addition, we examined the effect of acute administration of naltrexone on food intake in both ad-libitum-fed and food-deprived hamsters. We found that chronic systemic administration of naltrexone caused a significant increase in food intake and body weight. Second, acute administration of naltrexone decreased food intake after a 48-h fast but had no effect in ad-libitum-fed hamsters. Water consumption was not altered in any experimental paradigm. Our results suggest that opioid circuits in Syrian hamsters may function tonically to suppress food intake and body weight when Syrian hamsters are in positive energy balance. Paradoxically, opioids may enhance food intake after a sustained fast.