Anterior cingulate activity during pain-avoidance and reward tasks in monkeys
Anterior cingulate activity during pain-avoidance and reward tasks in monkeys
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DOI：
10.1016/s0168-0102(01)00197-3
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发表时间：
2001-04-01
影响因子：
2.9
通讯作者：
Mikami, A
中科院分区：
文献类型：
--
作者：
Koyama, T;Kato, K;Mikami, A
我们记录了形成辨别性疼痛回避和奖励任务的猕猴前扣带回皮质的单个神经元活动：先给出0.5-1.5%的S的预测线索，然后是1.0S的红色或绿色辨别线索(1：1，随机)：如果猴子在红色提示期间没有反应，就会给出痛苦的刺激；如果猴子在提示1 S延迟之后，如果猴子在绿色提示之后有反应，就会给予奖励。在所记录的775个神经元中，196个神经元在一个或多个观察期内表现出显著的活动：36个在预测期：77个在辨别期；41个在延迟期：85个在应答期；40个在奖赏前时段；15个在奖赏摄取期。在辨别期间被激活的77个神经元中，47个在红色(34个)或绿色(13)提示期间表现出专属活动；在85个反应期间被激活的神经元中，表现出专有活动(37个)或获得一种感觉(27个)。对照实验证实，神经元活动不能归因于简单的视觉或运动过程。这些结果表明，一些前扣带回神经元参与了对即将发生的事件的预期和反应选择。(C)2001年爱思唯尔爱尔兰科学有限公司和日本神经科学学会。版权所有。
We recorded single neuronal activities in the anterior cingulate cortex of monkeys while they were pel forming discriminative pain-avoidance and reward tasks: a prediction cue was presented for 0.5-1.5 s, followed by a red or green discrimination cue (1:1, random) for 1.0 s: painful stimuli were presented if the monkey failed to respond during the red cue; a reward was given, subsequent to a cued 1 s delay, if the monkey responded after the green cue. Among 775 neurons recorded, 196 neurons showed significant activity during one or more observation periods: 36 during the prediction period: 77 during the discrimination period; 41 during the delay period: 85 during the response period: 40 during the pre-reward period: and 15 during the reward-ingestion period. Of 77 neurons activated during the discrimination period, 47 showed exclusive activity either during the red (34) or during the green (13) cue: of 85 neurons activated during the response period, 64 showed exclusive activity either fur pain-avoidance (37) or obtaining a ren ard (27). Control experiments confirmed that the neuronal activity could not be attributed to simple visual or motor processes. The results suggest that some anterior cingulate neurons are involved with anticipation of, and response selection for, imminent events. (C) 2001 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.