Cortical activation to auditory mismatch elicited by frequency deviant and complex novel sounds:: A PET study
Cortical activation to auditory mismatch elicited by frequency deviant and complex novel sounds:: A PET study
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DOI：
10.1006/nimg.2002.1176
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发表时间：
2002-09-01
期刊：
影响因子：
5.7
通讯作者：
Müller, SP
中科院分区：
文献类型：
--
作者：
Müller, BW;Jüptner, M;Müller, SP
注意焦点外听觉异常事件的分析是人类信息处理的基本能力，在诱发电位研究中，已经在失配负波（MMN）和P3a成分的实验中进行了研究。然而，为这些组件做出贡献的发电机仍在讨论中。在这里，我们评估皮质血流听觉刺激在三种情况下。6名健康受试者分别接受标准音、频率偏差音（MMN条件）和复杂新奇音（新奇条件），同时注意力被引导至非要求性视觉任务。MMN条件与标准条件对比分析显示左右上级颞回、右上级颞沟和左额下回的血流变化。与标准条件相比，复杂的新奇声音激活左侧上级颞回和左侧额下回和额中回。左侧海马旁回出现小的皮质下激活，右侧上级颞回出现广泛激活。当控制偏差概率时，新的声音激活了右额下回。与以前的研究相比，我们的研究结果表明，左半球的贡献额颞叶网络的听觉偏差处理。我们的研究结果提供了进一步的证据，额叶皮层的贡献以外的听觉偏差的集中注意力的处理。(C)2002 Elsevier Science（美国）。
The analysis of auditory deviant events outside the focus of attention is a fundamental capacity of human information processing and has been studied in experiments on Mismatch Negativity (MMN) and the P3a component in evoked potential research. However, generators contributing to these components are still under discussion. Here we assessed cortical blood flow to auditory stimulation in three conditions. Six healthy subjects were presented with standard tones, frequency deviant tones (MMN condition), and complex novel sounds (Novelty condition), while attention was directed to a nondemanding visual task. Analysis of the MMN condition contrasted with the standard condition revealed blood flow changes in the left and right superior temporal gyrus, right superior temporal sulcus and left inferior frontal gyrus. Complex novel sounds contrasted with the standard condition activated the left superior temporal gyrus and the left inferior and middle frontal gyrus. A small subcortical activation emerged in the left parahippocampal gyrus and an extended activation was found covering the right superior temporal gyrus. Novel sounds activated the right inferior frontal gyrus when controlling for deviance probability. In contrast to previous studies our results indicate a left hemisphere contribution to a frontotemporal network of auditory deviance processing. Our results provide further evidence for a contribution of the frontal cortex to the processing of auditory deviance outside the focus of directed attention. (C) 2002 Elsevier Science (USA).