Defective deep placentation
Defective deep placentation
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DOI：
10.1016/j.bpobgyn.2010.10.012
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发表时间：
2011-06-01
影响因子：
5.5
通讯作者：
Brosens, Ivo
中科院分区：
文献类型：
--
作者：
Khong, Yee;Brosens, Ivo
深度胎盘缺损的特征是子宫-胎盘动脉重构缺损。在某些情况下，其特征还表现为动脉病变，如急性动脉粥样硬化和血管内滋养细胞的持续存在。该病与妊娠期间的一系列并发症有关，包括先兆子痫、宫内生长受限、早产、胎膜早破、晚期散发性流产和胎盘早剥。基于重构限制程度和螺旋动脉肌层段存在阻塞性病变，提出了将深部胎盘缺陷分为三种类型的标准。尽管潜在的机制尚不清楚，但有证据表明深层胎盘缺陷的起源可能不是滋养细胞的原发性缺陷，而是在胎盘之前或早期阶段子宫内膜和内肌层的异常。(C) 2010 Elsevier Ltd.版权所有。
Defective deep placentation is characterised by defective remodelling of the utero-placental arteries. Under certain conditions, it is also characterised by the presence of arterial lesions, such as acute atherosis and the persistence of endovascular trophoblast. The condition has been associated with a spectrum of complications during pregnancy, including pre-eclampsia, intrauterine growth restriction, pre-term birth, pre-term premature rupture of membranes, late sporadic miscarriage and abruptio placentae. Criteria are proposed for the classification of defective deep placentation into three types based on the degree of restriction of remodelling and the presence of obstructive lesions in the myometrial segment of the spiral arteries. Although the underlying mechanisms are not understood, evidence is emerging that the origin of defective deep placentation may not lie in primary defect of the trophoblast, but in abnormailities of the endometrium and inner myometrium before or during the early stages of placentation. (C) 2010 Elsevier Ltd. All rights reserved.