Mixed mania associated with tricyclic antidepressant therapy in prepubertal delusional depression: three cases.
Mixed mania associated with tricyclic antidepressant therapy in prepubertal delusional depression: three cases.
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青春期前妄想性抑郁症与三环类抗抑郁药治疗相关的混合躁狂：三例。
DOI：
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发表时间：
1998
影响因子：
1.9
通讯作者：
M. Strober
中科院分区：
文献类型：
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作者：
M. Strober
本报告描述了三名患有妄想性抑郁症的儿童在开始三环类抗抑郁药治疗后不久突然出现混合躁狂症。这一观察结果与将严重抑郁青少年的精神运动异常和精神病与躁狂转换倾向增加联系起来的报告一致，也与成人研究报告一致，这些研究报告与单相情感疾病相比，双相情感疾病抗抑郁药物诱发的循环风险更大。所描述的病例表明，在患有严重抑郁症的青少年中考虑使用三环药物治疗时需要谨慎。
This report describes the sudden appearance of mixed mania in three children with delusional depression soon after the commencement of tricyclic antidepressant therapy. The observation is consistent with reports linking psychomotor abnormalities and psychosis in severely depressed juveniles to an increased propensity for manic switching, as well as adult studies that report a greater risk of antidepressant-induced cycling in bipolar compared with unipolar affective illness. The cases described suggest the need for caution when considering tricyclic pharmacotherapy in juveniles with severe depressive disease.