Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: Findings from CALGB 89803
Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: Findings from CALGB 89803
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DOI：
10.1200/jco.2006.06.0863
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发表时间：
2006-08-01
影响因子：
45.3
通讯作者：
Fuchs, Charles S.
中科院分区：
文献类型：
--
作者：
Meyerhardt, Jeffrey A.;Heseltine, Denise;Fuchs, Charles S.
目的定期的体力活动降低发展结肠癌的风险，然而，其对患者的影响与建立disease是unknown.Patients和方法我们进行了一项前瞻性观察研究，832例III期结肠癌患者参加了一项随机辅助化疗试验。患者在完成治疗后约6个月报告了各种娱乐性体力活动，并观察复发或死亡。为了尽量减少隐性复发的偏倚，我们排除了复发或在90天内死亡的患者，他们的体力活动assessment.Results与每周从事少于3个代谢当量任务（MET）小时的体力活动的患者相比，无病生存的校正风险比为0.51（95% CI，0.26至0.97），每周18至26.9 MET小时，每周27或更多MET小时为0.55（95% CI，0.33至0.91）。调整后的趋势P值为0.01。诊断后活动与无复发生存率（趋势P = 0.03）和总生存率（趋势P = 0.01）的改善相似。与体力活动相关的获益不受性别、体重指数、阳性淋巴结数量、年龄、基线体力状态或接受化疗的影响。此外，受益保持不变，即使排除参与者谁开发癌症复发或死亡6个月内的活动assessment.Conclusion手术切除和术后辅助化疗的III期结肠癌，对于患者谁生存和复发免费约6个月后辅助化疗，体力活动似乎可以降低癌症复发和死亡的风险。
Purpose Regular physical activity reduces the risk of developing colon cancer, however, its influence on patients with established disease is unknown.Patients and Methods We conducted a prospective observational study of 832 patients with stage III colon cancer enrolled in a randomized adjuvant chemotherapy trial. Patients reported on various recreational physical activities approximately 6 months after completion of therapy and were observed for recurrence or death. To minimize bias by occult recurrence, we excluded patients who experienced recurrence or died within 90 days of their physical activity assessment.Results Compared with patients engaged in less than three metabolic equivalent task (MET) -hours per week of physical activity, the adjusted hazard ratio for disease-free survival was 0.51 (95% CI, 0.26 to 0.97) for 18 to 26.9 MET-hours per week and 0.55 (95% CI, 0.33 to 0.91) for 27 or more MET-hours per week. The adjusted P for trend was .01. Postdiagnosis activity was associated with similar improvements in recurrence-free survival (P for trend = .03) and overall survival (P for trend = .01). The benefit associated with physical activity was not significantly modified by sex, body mass index, number of positive lymph nodes, age, baseline performance status, or chemotherapy received. Moreover, the benefit remained unchanged even after excluding participants who developed cancer recurrence or died within 6 months of activity assessment.Conclusion Beyond surgical resection and postoperative adjuvant chemotherapy for stage III colon cancer, for patients who survive and are recurrence free approximately 6 months after adjuvant chemotherapy, physical activity appears to reduce the risk of cancer recurrence and mortality.