Enter at your own risk: how enteroviruses navigate the dangerous world of pattern recognition receptor signaling.
Enter at your own risk: how enteroviruses navigate the dangerous world of pattern recognition receptor signaling.
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DOI：
10.1016/j.cyto.2013.05.007
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发表时间：
2013-09
期刊：
影响因子：
3.8
通讯作者：
Coyne, Carolyn B.
中科院分区：
文献类型：
--
作者：
Harris, Katharine G.;Coyne, Carolyn B.
肠病毒是世界上最常见的人类病毒病原体。这类小的、无包膜的单链RNA病毒包括柯萨奇病毒、鼻病毒、埃可病毒和脊髓灰质炎病毒。感染这些病毒可引起类似普通感冒的轻微症状，但也可能与更严重的综合征相关，如脊髓灰质炎、包括无菌性脑膜炎和脑炎在内的神经系统疾病、心肌炎和I型糖尿病的发病。在人类中，排列在呼吸道和/或消化道的极化上皮细胞代表肠道病毒感染的初始部位。宿主感染的控制是通过多种模式识别受体（PRRs）的参与而启动的。PRRs充当先天免疫系统的哨兵，提醒宿主病毒入侵者的存在。这篇综述收集了现有的数据，说明了PRR在肠病毒感染反应中的作用，以及肠病毒中断和操纵PRR信号以增强自身复制的无数方式，从而诱导人类疾病。
Enteroviruses are the most common human viral pathogens worldwide. This genus of small, non-enveloped, single stranded RNA viruses includes coxsackievirus, rhinovirus, echovirus, and poliovirus species. Infection with these viruses can induce mild symptoms that resemble the common cold, but can also be associated with more severe syndromes such as poliomyelitis, neurological diseases including aseptic meningitis and encephalitis, myocarditis, and the onset of type I diabetes. In humans, polarized epithelial cells lining the respiratory and/or digestive tracts represent the initial sites of infection by enteroviruses. Control of infection in the host is initiated through the engagement of a variety of pattern recognition receptors (PRRs). PRRs act as the sentinels of the innate immune system and serve to alert the host to the presence of a viral invader. This review assembles the available data annotating the role of PRRs in the response to enteroviral infection as well as the myriad ways by which enteroviruses both interrupt and manipulate PRR signaling to enhance their own replication, thereby inducing human disease.
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影响因子：
8.8
作者：
Feng Q;Hato SV;Langereis MA;Zoll J;Virgen-Slane R;Peisley A;Hur S;Semler BL;van Rij RP;van Kuppeveld FJ
通讯作者：
van Kuppeveld FJ
影响因子：
64.8
作者：
Alexopoulou, L;Holt, AC;Flavell, RA
通讯作者：
Flavell, RA
DOI：
10.1073/pnas.74.3.961
发表时间：
1977-01-01
影响因子：
11.1
作者：
FLANEGAN, JB;PETTERSSON, RF;BALTIMORE, D
通讯作者：
BALTIMORE, D
影响因子：
30.3
作者：
Coyne CB;Bozym R;Morosky SA;Hanna SL;Mukherjee A;Tudor M;Kim KS;Cherry S
通讯作者：
Cherry S
影响因子：
6.7
作者：
Balachandran S;Beg AA
通讯作者：
Beg AA