Single-unit activity related to bimanual arm movements in the primary and supplementary motor cortices
Single-unit activity related to bimanual arm movements in the primary and supplementary motor cortices
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DOI：
10.1152/jn.00335.2001
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发表时间：
2002-12-01
影响因子：
2.5
通讯作者：
Vaadia, E
中科院分区：
文献类型：
--
作者：
Donchin, O;Gribova, A;Vaadia, E
记录了单臂(单手)和双臂(双手)近端触达任务的恒河猴的主运动(MI)和辅助运动(SMA)区的单个单位。在双手动作的执行过程中，每个区域约一半的神经元(MI：129/232，SMA：107/206)的任务相关活动与一只手臂类似移位时的活动不同，而另一只手臂是静止的。这种“双手相关”活动的大部分不能用单手达到过程中的任何线性活动组合来解释，也不能用运动学或记录的肌电活动的差异来解释。与双手相关的活动对肌肉活动或手臂运动学的一次又一次的变化相对不敏感。例如，双手操作的手臂运动与单手操作的对照相比差异最大的试验，与观察到最大的双手操作神经影响的试验并不相符。通过使用表面标志、肌电记录、微刺激和感觉测试的混合方法建立的皮质定位表明，所记录的神经元并不局限于特定涉及姿势肌肉的区域。通过拒绝这一系列的替代解释，我们得出结论，MI和SMA的神经活动可以反映与双手运动相关的专门的皮质处理。
Single units were recorded from the primary motor (MI) and supplementary motor (SMA) areas of Rhesus monkeys performing one-arm (unimanual) and two-arm (bimanual) proximal reaching tasks. During execution of the bimanual movements, the task related activity of about one-half the neurons in each area (MI: 129/232, SMA: 107/206) differed from the activity during similar displacements of one arm while the other was stationary. The bulk of this "bimanual-related" activity could not be explained by any linear combination of activities during unimanual reaching or by differences in kinematics or recorded EMG activity. The bimanual-related activity was relatively insensitive to trial-to-trial variations in muscular activity or arm kinematics. For example, trials where bimanual arm movements differed the most from their unimanual controls did not correspond to the ones where the largest bimanual neural effects were observed. Cortical localization established by using a mixture of surface landmarks, electromyographic recordings, microstimulation, and sensory testing suggests that the recorded neurons were not limited to areas specifically involved with postural muscles. By rejecting this range of alternative explanations, we conclude that neural activity in MI as well as SMA can reflect specialized cortical processing associated with bimanual movements.