Patterns of atrophy in pathologically confirmed dementias: a voxelwise analysis.
Patterns of atrophy in pathologically confirmed dementias: a voxelwise analysis.
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DOI：
10.1136/jnnp-2016-314978
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Schott JM
中科院分区：
文献类型：
--
作者：
Harper L;Bouwman F;Burton EJ;Barkhof F;Scheltens P;O'Brien JT;Fox NC;Ridgway GR;Schott JM
影像被推荐用来支持痴呆的临床诊断，但影像研究很少有疾病的病理证实。这项研究的目的是描述六种主要病理疾病的脑体积丢失模式，并与对照组和彼此进行比较。186名经临床诊断为痴呆症并经病理组织学证实的患者和73名健康对照纳入本研究。基于体素的形态计量学，基于临死前的T1加权MRI，被用来识别横断面组的脑体积差异。早发性阿尔茨海默病和晚发性阿尔茨海默病表现出不同的灰质体积丢失模式，早发组更广泛地累及顶叶，而晚发组则更多地表现为局灶性内侧颞叶丢失。早老素-1组与早发组的顶叶受累相似，丘脑、内侧颞叶和颞叶新皮质局限性体积减少。虽然与其他病理组相比，中央前回/中央后回体积减小，但与其他病理类型相比，路易体病理与广泛的体积丢失相关。Tau和TDP43A的病理表现相似的额颞叶体积丢失模式，尽管在4次tau组右侧范围较小，在TDP43A组中顶叶受累较多。TDP43C组显示左侧前颞叶受累更大。与对照组和其他痴呆相比，病理上不同的痴呆表现出区域性体积减少的特征模式。在这些队列中发现的体素差异突出了成像特征，这可能有助于在生活中区分痴呆症亚型。这项研究的结果可通过Neurovault(http://neurovault.org/collections/ADHMHOPN/).进行进一步检查
Imaging is recommended to support the clinical diagnoses of dementias, yet imaging research studies rarely have pathological confirmation of disease. This study aims to characterise patterns of brain volume loss in six primary pathologies compared with controls and to each other. One hundred and eighty-six patients with a clinical diagnosis of dementia and histopathological confirmation of underlying pathology, and 73 healthy controls were included in this study. Voxel-based morphometry, based on ante-mortem T1-weighted MRI, was used to identify cross-sectional group differences in brain volume. Early-onset and late-onset Alzheimer’s disease exhibited different patterns of grey matter volume loss, with more extensive temporoparietal involvement in the early-onset group, and more focal medial temporal lobe loss in the late-onset group. The Presenilin-1 group had similar parietal involvement to the early-onset group with localised volume loss in the thalamus, medial temporal lobe and temporal neocortex. Lewy body pathology was associated with less extensive volume loss than the other pathologies, although precentral/postcentral gyri volume was reduced in comparison with other pathological groups. Tau and TDP43A pathologies demonstrated similar patterns of frontotemporal volume loss, although less extensive on the right in the 4-repeat-tau group, with greater parietal involvement in the TDP43A group. The TDP43C group demonstrated greater left anterior-temporal involvement. Pathologically distinct dementias exhibit characteristic patterns of regional volume loss compared with controls and other dementias. Voxelwise differences identified in these cohorts highlight imaging signatures that may aid in the differentiation of dementia subtypes during life. The results of this study are available for further examination via NeuroVault (http://neurovault.org/collections/ADHMHOPN/).
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影响因子：
9.9
作者：
Jack, CR;Petersen, RC;Kokmen, E
通讯作者：
Kokmen, E
影响因子：
9.9
作者：
Cash DM;Ridgway GR;Liang Y;Ryan NS;Kinnunen KM;Yeatman T;Malone IB;Benzinger TL;Jack CR Jr;Thompson PM;Ghetti BF;Saykin AJ;Masters CL;Ringman JM;Salloway SP;Schofield PR;Sperling RA;Cairns NJ;Marcus DS;Xiong C;Bateman RJ;Morris JC;Rossor MN;Ourselin S;Fox NC;Dominantly Inherited Alzheimer Network (DIAN)
通讯作者：
Dominantly Inherited Alzheimer Network (DIAN)
DOI：
10.1016/j.jalz.2011.03.005
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
McKhann GM;Knopman DS;Chertkow H;Hyman BT;Jack CR Jr;Kawas CH;Klunk WE;Koroshetz WJ;Manly JJ;Mayeux R;Mohs RC;Morris JC;Rossor MN;Scheltens P;Carrillo MC;Thies B;Weintraub S;Phelps CH
通讯作者：
Phelps CH
影响因子：
4.2
作者：
Nedelska Z;Ferman TJ;Boeve BF;Przybelski SA;Lesnick TG;Murray ME;Gunter JL;Senjem ML;Vemuri P;Smith GE;Geda YE;Graff-Radford J;Knopman DS;Petersen RC;Parisi JE;Dickson DW;Jack CR Jr;Kantarci K
通讯作者：
Kantarci K
影响因子：
9.9
作者：
Rohrer, J. D.;Geser, F.;Seeley, W. W.
通讯作者：
Seeley, W. W.