Dysembryoplastic neuroepithelial tumour Features in 16 patients
Dysembryoplastic neuroepithelial tumour Features in 16 patients
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胚胎发育不良性神经上皮肿瘤16例特点
DOI：
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
B. Neville
中科院分区：
文献类型：
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作者：
A. Raymond;S. Halpin;N. Alsanjari;M. Cook;N. Kitchen;D. Fish;J. Stevens;B. Harding;F. Scaravilli;B. Kendall;S. Shorvon;B. Neville
胚胎发育不良性神经上皮瘤（DNT）是一种新发现的脑肿块病变，具有独特的病理特征和良好的预后。我们回顾了 16 例接受手术的 DNT 患者的临床、脑电图、神经影像和病理特征；只有一名患者没有癫痫。癫痫发作时的平均年龄为 9.5 岁（范围：1 周至 30 岁），手术时的平均年龄为 17 岁（范围：7 个月至 37 岁）。平均言语智商为 94.6（范围：79-110），表现智商为 105（范围：79-130）（n = 10），所有病例的脑电图均异常（n = 13）：12 名患者出现局部缓慢活动，10 名患者出现发作间期尖峰，3 名患者的病灶范围小于病灶范围或与病灶一致，3 名患者的病灶范围比病灶更广泛或距离病灶较远。七。 11 名患者中有 3 名 X 射线 CT 正常。磁共振成像提供了详细的解剖信息：病变主要位于皮质内，尽管在六名患者中也有白质受累。除了一名患者的病变位于扣带回外，所有患者的病变均涉及颞叶。在颞叶病例中，MRI 显示 14 名患者中有 11 名病变累及或接近颞叶内侧结构。其他磁共振特征包括：长 TE/TR 图像上的局限性高信号（10 名患者）、短 TR 图像上的低信号（12 名患者）和囊肿形成（5 名患者）。 CT 上发现 4 名患者有钙化。术后随访时间为 8 至 30 个月（平均 16.2 个月）：12 名患者无癫痫发作，其中 2 名患者癫痫发作频率降低了 80% 以上（n = 14）。组织病理学特征包括所有病例的异质成分、钙化（13 例）、发育不良特征（12 例）和孤立的软膜下扩散病灶（5 例）。 12 例中偶尔出现有丝分裂，6 例中出现对增殖细胞核抗原的免疫反应，表明这些病变具有细胞增殖活性，可能需要在术后对这些患者进行随访。
Dysembryoplastic neuropithelial tumour (DNT) is a newly recognized brain mass lesion with distinctive pathological features and a favourable prognosis. We reviewed the clinical, electroencephalographic, neuroimaging and pathological features of 16 patients with DNT who underwent surgery; only one patient did not have epilepsy. Mean age at seizure onset was 9.5 years (range: 1 week to 30 years) and surgery 17 years (range: 7 months to 37 years). The mean verbal IQ was 94.6 (range: 79–110) and performance IQ 105 (range: 79–130) (n = 10), The EEG was abnormal in all cases reviewed (n = 13): localized slow activity was seen in 12 and interictal spiking in 10 patients, being less extensive than or concordant with the lesion in three and more extensive than or distant to the lesion in seven. X-ray CT was normal in three out of 11 patients. Magnetic resonance imaging provided detailed anatomical information: the lesion was predominantly intracortical, although in six patients, there was also white matter involvement. The lesion involved the temporal lobe in all but one patient where it was in the cingulate gyrus. Of the temporal lobe cases, MRI showed that the lesion involved, or was in close proximity to, mesial temporal structures in 11 out of 14 patients. Other magnetic resonance features included: circumscribed hyperintensity on long TE/TR images (10 patients), hypointensity on short TR images (12 patients), and cyst formation (five patients). Calcification was seen on CT in four patients. Post surgical follow-up ranged from 8 to 30 months (mean 16.2 months): 12 patients are seizure free and two have a >80% reduction in seizure frequency (n = 14). Histopathological characteristics included a heterogeneous composition in all cases, Calcification (13 cases), dysplastic features (12 cases) and isolated foci of subpial spread (five cases). The presence of occasional mitoses in 12 cases and immunoreactivity to the proliferating cell nuclear antigen in six cases indicate that these lesions have cellular proliferative activity and that there may be a need to follow these patients postoperatively.
核磁共振显示大脑异常：与 CT 比较。
DOI：
10.2214/ajr.140.5.847
发表时间：
1983
期刊：
AJR. American journal of roentgenology
影响因子：
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作者：
Brant-Zawadzki,M;Davis,PL;Crooks,LE;Mills,CM;Norman,D;Newton,TH;Sheldon,P;Kaufman,L
通讯作者：
Kaufman,L