Catalytic Suzuki coupling reactions by amido phosphine complexes of palladium
Catalytic Suzuki coupling reactions by amido phosphine complexes of palladium
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DOI：
10.1021/om0492395
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发表时间：
2005-01-31
期刊：
影响因子：
2.8
通讯作者：
Huang, MH
中科院分区：
文献类型：
--
作者：
Liang, LC;Chien, PS;Huang, MH
用[NP]Li(THF)(2) ([NP]（-) = N-（2-（二苯基膦）苯基）2,6-二异丙基苯胺）在THF中处理PdCl2(PhCN)(2)得到二聚体{[NP] PdCl}(2)，该二聚体与三环己基膦反应生成[NP]PdCl（PCy3）。溶液核磁共振和x射线晶体学研究表明，[NP]PdCl（PCy3）中的两个给磷体是相互顺式的。{[NP]PdCl}(2)和[NP]PdCl（PCy3）都是多种芳基卤化物铃木偶联反应的高活性催化剂前体，包括那些具有电子失活和空间阻碍特征的芳基卤化物。
Treatment of PdCl2(PhCN)(2) with [NP]Li(THF)(2) ([NP](-) = N-(2-(diphenylphosphino)phenyl)2,6-diisopropylanilide) in THF affords dimeric {[NP] PdCl}(2), which reacts with tricyclohexylphosphine to produce [NP]PdCl(PCy3). The two phosphorus donors in [NP]PdCl(PCy3) are mutually cis, as indicated by the solution NMR and X-ray crystallographic studies. Both {[NP]PdCl}(2) and [NP]PdCl(PCy3) are highly active catalyst precursors for Suzuki coupling reactions of a wide array of aryl halides, including those featuring electronically deactivated and sterically hindered characteristics.