Coherent slow cortical potentials reveal a superior localization of resting-state functional connectivity using voltage-sensitive dye imaging
Coherent slow cortical potentials reveal a superior localization of resting-state functional connectivity using voltage-sensitive dye imaging
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相干慢皮层电位揭示了使用电压敏感染料成像的静息态功能连接的优越定位
DOI：
10.1016/j.neuroimage.2014.01.004
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发表时间：
2014-05-01
期刊：
影响因子：
5.7
通讯作者：
Li, Pengcheng
中科院分区：
文献类型：
--
作者：
Li, Bing;Liu, Rui;Li, Pengcheng
自发性血流动力学波动的静息状态功能连接（RSFC）被广泛用于研究基于神经血管机制的大尺度脑功能网络。然而，基于神经活动的高分辨率RSFC网络尚未公开，以探索这些自发血流动力学信号的神经基础。本研究利用电压敏感染料（VSDs）光学成像技术在高空间分辨率下研究了小鼠的神经RSFC网络。结果表明，皮层慢电位（0.1 ~ 4 Hz）的RSFC网络与自发性血流动力学信号的RSFC网络具有相似的相关模式，表明休息时皮层慢电位与自发性血流动力学信号之间存在紧密耦合，但皮层慢电位的RSFC网络的双侧对称性明显低于自发性血流动力学信号。此外，在刺激小鼠爪子后，在双侧皮层之间也可以发现类似的不对称神经激活模式。通过增加麻醉水平来诱导意识的减少，慢皮层电位的RSFC网络持续存在，但自发血流动力学信号的RSFC网络变得离散。这些结果表明，连贯的皮层慢电位是自发血流动力学波动的基础，并揭示了RSFC网络的优越定位。VSD成像可能用于检查神经活动的RSFC，特别是在神经血管耦合受损的情况下。(C) 2014 Elsevier Inc .版权所有
The resting-state functional connectivity (RSFC) of spontaneous hemodynamic fluctuations is widely used to investigate large-scale functional brain networks based on neurovascular mechanisms. However, high-resolution RSFC networks based on neural activity have not been disclosed to explore the neural basis of these spontaneous hemodynamic signals. The present study examines the neural RSFC networks in mice at high spatial resolution using optical imaging with voltage-sensitive dyes (VSDs). Our results show that neural RSFC networks for the slow cortical potentials (0.1-4 Hz) showed similar correlation patterns to the RSFC networks for the spontaneous hemodynamic signals, indicating a tight coupling between the slow cortical potential and the spontaneous hemodynamic signals during rest, but the bilateral symmetry of the RSFC networks for the slow cortical potentials was significantly lower than that for the spontaneous hemodynamic signals. Moreover, similar asymmetric neural activation patterns could also be found between the bilateral cortexes after stimulating the paws of mice. By increasing anesthetic levels to induce the reduction of consciousness, the RSFC networks for the slow cortical potentials persisted, but those for the spontaneous hemodynamic signals became discrete. These results suggest that the coherent slow cortical potentials underlie the spontaneous hemodynamic fluctuations and reveal a superior localization of RSFC networks. VSD imaging may potentially be used to examine the RSFC of neural activity, particularly under conditions of impaired neurovascular coupling. (C) 2014 Elsevier Inc All rights reserved.