Iridium-Catalyzed C4-Alkylation of 2,6-Di-tert-butylphenol by Using Hydrogen-Borrowing Catalysis
Iridium-Catalyzed C4-Alkylation of 2,6-Di-tert-butylphenol by Using Hydrogen-Borrowing Catalysis
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DOI：
10.1055/s-0035-1561439
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发表时间：
2017-02-01
影响因子：
2.6
通讯作者：
Donohoe, Timothy J.
中科院分区：
文献类型：
--
作者：
Frost, James R.;Cheong, Choon Boon;Donohoe, Timothy J.
已经开发了铱催化的氢借用方法，由此可以通过使用一系列伯醇在C4-位烷基化2，6-二叔丁基（11个实施例，40-93%产率）。在此之后，所获得的产物的选择经历逆弗里德尔-克拉夫茨反应，以提供pam-取代的苯酚，其可以潜在地经历进一步的合成操作。
An iridium-catalyzed hydrogen-borrowing process has been developed whereby 2,6-di-tert-buty can be alkylated at the C4-position by using a range of primary alcohols (11 examples, 40-93% yield). Following this, a selection of the products obtained underwent retro-Friedel-Crafts reactions to provide pam-substituted phenols, which could potentially undergo further synthetic manipulations.