Nanoparticles for Interrogation of Cell Signaling.
Nanoparticles for Interrogation of Cell Signaling.
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DOI：
10.1146/annurev-anchem-092822-085852
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发表时间：
2023-06
期刊：
影响因子：
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通讯作者：
Seonik Lee;Mengchi Jiao;Zihan Zhang;Yan Yu
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文献类型：
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作者：
Seonik Lee;Mengchi Jiao;Zihan Zhang;Yan Yu
细胞功能依赖于信号转导——将细胞外信号传递到细胞内部的分子相互作用和生化反应的级联反应。解剖控制信号转导过程的原理对细胞生理学的基本理解和生物医学干预的发展至关重要。然而，细胞信号传导的复杂性超出了传统生物化学分析所能达到的范围。由于其独特的物理和化学性质，纳米颗粒（NPs）越来越多地用于细胞信号的定量测量和操作。尽管这一领域的研究仍处于起步阶段，但它有可能产生新的、改变范式的细胞生物学知识，并导致生物医学创新。为了强调这一点的重要性，我们在这篇综述中总结了NPs在细胞信号传导中的开发和应用的研究，从信号分子的定量测量到细胞信号转导的时空操纵。
Cell functions rely on signal transduction—the cascades of molecular interactions and biochemical reactions that relay extracellular signals to the cell interior. Dissecting principles governing the signal transduction process is critical for the fundamental understanding of cell physiology and the development of biomedical interventions. The complexity of cell signaling is, however, beyond what is accessible by conventional biochemistry assays. Thanks to their unique physical and chemical properties, nanoparticles (NPs) have been increasingly used for the quantitative measurement and manipulation of cell signaling. Even though research in this area is still in its infancy, it has the potential to yield new, paradigm-shifting knowledge of cell biology and lead to biomedical innovations. To highlight this importance, we summarize in this review studies that pioneered the development and application of NPs for cell signaling, from quantitative measurements of signaling molecules to spatiotemporal manipulation of cell signal transduction.