Vibrio parahaemolyticus: a review on the pathogenesis, prevalence, and advance molecular identification techniques.

Vibrio parahaemolyticus: a review on the pathogenesis, prevalence, and advance molecular identification techniques.
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弧菌偏溶血:关于发病率,患病率和提高分子鉴定技术的综述。

DOI:
10.3389/fmicb.2014.00705
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发表时间:
2014
影响因子:
5.2
通讯作者:
Lee LH
Lee LH
中科院分区:
生物学2区
文献类型:
--
作者:
Letchumanan V;Chan KG;Lee LH

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副溶血性弧菌是一种革兰氏阴性嗜盐细菌,广泛存在于河口、海洋和沿海环境中。副溶血性弧菌是人类因食用生的、未煮熟的或处理不当的海产品而导致的急性胃肠炎的主要病原体。在极少数情况下,副溶血性弧菌会导致伤口感染、耳朵感染或有既往疾病的个人败血症。副溶血性弧菌有两种溶血素毒力因子,一种是耐热的直接溶血素(TdH),它是一种促进细菌侵袭的致孔蛋白;另一种是TdH相关的溶血素(Trh),它在疾病发病机制中起着与TdH相似的作用。此外,该细菌还对粘连和III型分泌系统(T3SS1和T3SS2)进行编码,以确保其在环境中生存。本文就副溶血性弧菌的生长特点、致病机理、流行情况及分子鉴定技术的研究进展作一综述。
Vibrio parahaemolyticus is a Gram-negative halophilic bacterium that is found in estuarine, marine and coastal environments. V. parahaemolyticus is the leading causal agent of human acute gastroenteritis following the consumption of raw, undercooked, or mishandled marine products. In rare cases, V. parahaemolyticus causes wound infection, ear infection or septicaemia in individuals with pre-existing medical conditions. V. parahaemolyticus has two hemolysins virulence factors that are thermostable direct hemolysin (tdh)-a pore-forming protein that contributes to the invasiveness of the bacterium in humans, and TDH-related hemolysin (trh), which plays a similar role as tdh in the disease pathogenesis. In addition, the bacterium is also encodes for adhesions and type III secretion systems (T3SS1 and T3SS2) to ensure its survival in the environment. This review aims at discussing the V. parahaemolyticus growth and characteristics, pathogenesis, prevalence and advances in molecular identification techniques.
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