Histogram analysis of stretched-exponential and monoexponential diffusion-weighted imaging models for distinguishing low and intermediate/high gleason scores in prostate carcinoma
Histogram analysis of stretched-exponential and monoexponential diffusion-weighted imaging models for distinguishing low and intermediate/high gleason scores in prostate carcinoma
复制标题
用于区分前列腺癌低和中/高格里森评分的拉伸指数和单指数扩散加权成像模型的直方图分析
DOI：
10.1002/jmri.25958
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发表时间：
2018-08-01
影响因子：
4.4
通讯作者：
Zhou, Liang P.
中科院分区：
文献类型：
--
作者：
Liu, Wei;Liu, Xiao H.;Zhou, Liang P.
背景：评估前列腺癌侵袭性的非侵入性方法可能对患者有益。目的探讨扩展指数和单指数扩散加权成像（DWI）对前列腺癌侵袭性的预测价值。研究类型：前瞻性研究。研究对象：PCa患者75例。使用b值0、500、1000和2000 s/mm进行场强3t DWI检查(2)。本研究基于全肿瘤直方图分析，参照标准为根治性前列腺切除术。统计学检验直方图变量与Gleason分级组（GG）之间的相关性分析采用Spearman秩序分析。使用受试者工作特征（ROC）回归分析这些直方图变量区分低级别（LG）和中/高级别（HG） PCa的能力。结果表观扩散系数（ADC）和分布扩散系数（DDC）的百分位数和平均值与GG呈显著相关（0.414 ~ 0.593），而数值、偏度和峰度与GG无显著相关（0.034 ~ 0.323）。HG肿瘤(ADC:484136、592139、670144、788146、895 +/- 141mm(2)/s；DDC: 410 +/- 142、532 +/- 172、666 +/- 193、786 +/- 196、914 +/- 181mm(2)/s)在10（th）、25（th）、50（th）、75（th）个百分位数和平均值上低于LG肿瘤(ADC: 644 +/- 779、737 +/- 84、836 +/- 83、919 +/- 82、997 +/- 107mm(2)/s；监护系统:552 + / - 82,680 + / - 94,829 + / - 112,931 + / - 106、1045 + / - 100毫米(2)/ s)。然而，LG和HG肿瘤在价值（0.671 +/- 0.041 vs. 0.633 +/- 0.114）、峰度（ADC 0.09 vs. 0.086; DDC -0.033 vs. -0.317）或偏度（ADC -0.036 vs. 0.073; DDC -0.063 vs. 0.136）方面没有差异。以上统计量为P
BackgroundNoninvasive measures to evaluate the aggressiveness of prostate carcinoma (PCa) may benefit patients.PurposeTo assess the value of stretched-exponential and monoexponential diffusion-weighted imaging (DWI) for predicting the aggressiveness of PCa.Study TypeRetrospective study.SubjectsSeventy-five patients with PCa.Field Strength3T DWI examinations were performed using b-values of 0, 500, 1000, and 2000 s/mm(2).AssessmentThe research were based on entire-tumor histogram analysis and the reference standard was radical prostectomy.Statistical TestsThe correlation analysis was programmed with Spearman's rank-order analysis between the histogram variables and Gleason grade group (GG). Receiver operating characteristic (ROC) regression was used to analyze the ability of these histogram variables to differentiate low-grade (LG) from intermediate/high-grade (HG) PCa.ResultsThe percentiles and mean of apparent diffusion coefficient (ADC) and distributed diffusion coefficient (DDC) were correlated with GG (: 0.414-0.593), while there was no significant relation among value, skewnesses, and kurtosises with GG (:0.034-0.323). HG tumors (ADC:484136, 592139, 670144, 788146, 895 +/- 141mm(2)/s; DDC: 410 +/- 142, 532 +/- 172, 666 +/- 193, 786 +/- 196, 914 +/- 181mm(2)/s) had lower values in the 10(th), 25(th), 50(th), 75(th) percentiles and means than LG tumors (ADC: 644 +/- 779, 737 +/- 84, 836 +/- 83, 919 +/- 82, 997 +/- 107mm(2)/s; DDC: 552 +/- 82, 680 +/- 94, 829 +/- 112, 931 +/- 106, 1045 +/- 100mm(2)/s). However, there was no difference between LG and HG tumors in value (0.671 +/- 0.041 vs. 0.633 +/- 0.114), kurtosises (ADC 0.09 vs. 0.086; DDC -0.033 vs. -0.317), or skewnesses (ADC -0.036 vs. 0.073; DDC -0.063 vs. 0.136). The above statistics were P