Battling adhesions: from understanding to prevention.
Battling adhesions: from understanding to prevention.
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DOI：
10.1186/s42490-019-0005-0
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发表时间：
2019-01-01
影响因子：
--
通讯作者：
Zeugolis, Dimitrios I
中科院分区：
文献类型：
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作者：
Capella-Monsonis, Hector;Kearns, Stephen;Zeugolis, Dimitrios I
粘连是临床实践中的主要负担，特别是在腹部、子宫内、心包和肌腱外科手术后。粘连是由组织的上皮或间皮层的破坏引发的，由于纤维蛋白溶解活性的下调和纤维蛋白沉积的增加，导致纤维蛋白粘连位点。因此，参与组织愈合、凝血、炎症、纤维蛋白溶解和血管生成的代谢事件在粘连形成中起关键作用。了解这些事件，它们的相互作用及其对术后粘连发展的影响对于开发有效的治疗方法来预防它们至关重要。机械屏障、防粘剂及其组合通常用于对抗粘连。虽然这些系统似乎是有效的减少粘连在临床程序中，他们的预防仍然难以捉摸，强加需要新的抗粘连策略。
Adhesions represent a major burden in clinical practice, particularly following abdominal, intrauterine, pericardial and tendon surgical procedures. Adhesions are initiated by a disruption in the epithelial or mesothelial layer of tissue, which leads to fibrin adhesion sites due to the downregulation of fibrinolytic activity and an increase in fibrin deposition. Hence, the metabolic events involved in tissue healing, coagulation, inflammation, fibrinolysis and angiogenesis play a pivotal role in adhesion formation. Understanding these events, their interactions and their influence on the development of post-surgical adhesion is crucial for the development of effective therapies to prevent them. Mechanical barriers, antiadhesive agents and combination thereof are customarily used in the battle against adhesions. Although these systems seem to be effective at reducing adhesions in clinical procedures, their prevention remains still elusive, imposing the need for new antiadhesive strategies.