Antibacterial and antioxidant activity of Sutherlandia frutescens (Fabaceae), a reputed anti-HIV/AIDS phytomedicine

Antibacterial and antioxidant activity of Sutherlandia frutescens (Fabaceae), a reputed anti-HIV/AIDS phytomedicine
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DOI:
10.1002/ptr.1719
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发表时间:
2005-09-01
影响因子:
7.2
通讯作者:
Eloff, JN
Eloff, JN
中科院分区:
医学2区
文献类型:
--
作者:
Katerere, DR;Eloff, JN

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Dried ground leaves of Satherlandia frutescens were extracted by both sequential extraction with four solvents, starting with the least polar and separately with acetone, ethanol and water. The extracts were tested for antibacterial and antioxidant activity. The hexane extract was, generally, the most active extract against S. aureus, E. faecalis and E. coli with MIC values of 0.31, 1.25 and 2.50 mg/mL, respectively. The second method extracted compounds with antioxidant activity as shown by the DPPH free-radical scavenging assay. The use of Sutherlandia frutescens for topical staphylococcal infections, when formulated in an oily base appears to have a rational basis. Copyright (c) 2005 John Wiley & Sons, Ltd.