Vitamin D status and biomarkers of inflammation in runners.
Vitamin D status and biomarkers of inflammation in runners.
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DOI：
10.2147/oajsm.s31022
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发表时间：
2012
影响因子：
2.4
通讯作者：
Larson-Meyer DE
中科院分区：
文献类型：
--
作者：
Willis KS;Smith DT;Broughton KS;Larson-Meyer DE
维生素D的骨骼外功能-包括其在炎症调节中的作用-现在已经得到了很好的认可，但尚未在运动人群中进行研究。因此，本研究的目的是研究耐力运动员维生素D状态与促炎和抗炎细胞因子（作为炎症和免疫系统功能的标志物）之间的关系。我们分析了来自19名健康的、接受过耐力训练的男性和女性跑步者（遵循标准化饮食和运动方案）的空腹血液样本，用于维生素D状态（血清25-羟基维生素D [25（OH）D]）和特定血浆细胞因子浓度（肿瘤坏死因子α [TNF-α]、干扰素γ [IFN-γ]、白细胞介素[IL]-4和IL-10）。对血清/血浆浓度进行对数转换，并使用简单回归分析来确定25（OH）D和细胞因子浓度之间的显著相关性。42%的参与者维生素D不足[25（OH）D< 32 ng/mL]，而11%缺乏[25（OH）D < 20 ng/mL]。TNF-α和IL-4的变化范围分别为2.9 - 36.4 pg/mL和0 - 252.1 pg/mL。IFN-γ和IL-10的浓度极低，平均值分别为6.7 ± 7.0 pg/mL和4.8 ± 5.1 pg/mL。回归分析显示25（OH）D与TNF-α浓度呈显著负相关（R2 = 56.5，P < 0.001），但与其他细胞因子IFN-γ、IL-4和IL-10之间无显著负相关（分别为P = 0.477、0.694和0.673）。这些结果呼吁进一步关注维生素D不足的流行，即使是在户外运动员中，并支持维生素D状态下降与一种特定的炎症标志物之间可能存在的联系。未来的研究是必要的，以确定是否增加炎症与维生素D状态降低的运动员可能会增加炎症相关损伤的风险。
The extra-skeletal functions of vitamin D - including its role in inflammatory modulation - are now well recognized but have not yet been investigated in an athletic population. Thus, the purpose of this study was to investigate the relationship between vitamin D status and pro- and anti-inflammatory cytokines (as markers of inflammation and immune system function) in endurance athletes. We analyzed fasting blood samples from 19 healthy, endurance-trained male and female runners (following a standardized diet and exercise regimen) for vitamin D status (serum 25-hydroxyvitamin D [25(OH)D)] and specific plasma cytokine concentrations (tumor necrosis factor alpha [TNF-α], interferon-gamma [IFN-γ], interleukin [IL]-4, and IL-10). Serum/plasma concentrations were log-transformed and simple regression analysis was used to determine significant associations between 25(OH)D and cytokine concentrations. Forty-two percent of participants had insufficient vitamin D status [25(OH)D< 32 ng/mL], whereas 11% were deficient [25(OH)D < 20 ng/mL]. TNF-α and IL-4 were variable, ranging from 2.9 to 36.4 pg/mL and 0 to 252.1 pg/mL, respectively. Concentrations of IFN-γ and IL-10 were minimal, with means of 6.7 ± 7.0 pg/mL and 4.8 ± 5.1 pg/mL, respectively. Regression analysis revealed a significant inverse association between 25(OH)D and TNF-α concentrations (R2 = 56.5, P < 0.001) but not between 25(OH)D and the remaining cytokines, IFN-γ, IL-4, and IL-10 (P = 0.477, 0.694, and 0.673, respectively). These results call further attention to the epidemic of vitamin D insufficiency, even in outdoor athletes, and support a possible link between decreased vitamin D status and one particular marker of inflammation. Future investigations are necessary to determine whether increased inflammation in athletes with reduced vitamin D status could increase risk for inflammation-related injury.