RESPIRATORY MUCOUS SECRETIONS IN PATIENTS WITH CYSTIC-FIBROSIS - RELATIONSHIP BETWEEN LEVELS OF HIGHLY SULFATED MUCIN COMPONENT AND SEVERITY OF THE DISEASE
RESPIRATORY MUCOUS SECRETIONS IN PATIENTS WITH CYSTIC-FIBROSIS - RELATIONSHIP BETWEEN LEVELS OF HIGHLY SULFATED MUCIN COMPONENT AND SEVERITY OF THE DISEASE
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DOI：
10.1016/0009-8981(83)90242-5
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发表时间：
1983-01-01
影响因子：
5
通讯作者：
SACHDEV, GP
中科院分区：
文献类型：
--
作者：
CHACE, KV;LEAHY, DS;SACHDEV, GP
囊性纤维化（CF）患者的气管支气管分泌物中蛋白质、DNA和唾液酸含量高于健康供体。CF分泌物中的中性己糖含量显著低于正常人分泌物。CF分泌物中的中性己糖和唾液酸水平随着疾病的严重程度增加而增加。疾病严重程度增加的患者分泌物中这些化学参数水平的改变是分泌物中粘蛋白含量水平增加的结果，特别是高度硫酸化的粘蛋白组分。由于粘蛋白在很大程度上被认为是分泌物粘弹性的原因，因此疾病严重程度增加的患者分泌物中高度硫酸化粘蛋白组分的水平提高可能导致流变学性质改变，从而降低分泌物的粘液纤毛转运。
The tracheobronchial secretions from cystic fibrosis (CF) patients contained higher levels of protein, DNA and sialic acid than the tracheobronchial secretions from healthy donors. The neutral hexose content in CF secretions was strikingly lower than in secretions from normal subjects. The levels of neutral hexose and sialic acid in the CF secretions were found to increase with increasing severity of the disease. The alterations in the levels of these chemical parameters in the secretions of patients with increased disease severity are as a result of increased levels of the mucin content of the secretions, especially of the highly sulfated mucin component. Since mucins are considered, to a large extent, responsible for the viscoelastic properties of the secretions, the enhanced levels of the highly sulfated mucin component in the secretions of the patients with increased disease severity, may contribute to altered rheological properties and hence decreased mucociliary transport of the secretions.