A MATHEMATICAL INSULIN-SECRETION MODEL AND ITS VALIDATION IN ISOLATED RAT PANCREATIC-ISLETS PERIFUSION
A MATHEMATICAL INSULIN-SECRETION MODEL AND ITS VALIDATION IN ISOLATED RAT PANCREATIC-ISLETS PERIFUSION
复制标题
胰岛素分泌数学模型及其在离体大鼠胰岛灌注中的验证
DOI：
10.1016/0010-4809(84)90021-1
复制
发表时间：
1984-01-01
期刊：
影响因子：
--
通讯作者：
ABE, H
中科院分区：
文献类型：
--
作者：
NOMURA, M;SHICHIRI, M;ABE, H
利用控制理论对葡萄糖诱导的胰岛素分泌进行分析，建立了胰岛素分泌的数学模型。为了验证模型，在离体大鼠胰岛灌流系统中获得的实验数据与模拟结果进行了比较。该模型的模拟研究与各种实验条件下的胰岛素反应吻合较好。葡萄糖诱导的胰岛β胰岛素分泌细胞被表示为具有一阶时滞的对葡萄糖输入的比例加微分响应的函数。无论葡萄糖浓度如何，葡萄糖浓度的负变化率都能抑制胰岛素分泌，达到负刺激的程度。该模型为分析胰岛素分泌动力学的生理意义和胰岛素分泌的临床研究提供了有用的研究工具。
A mathematical insulin-secretion model was constructed by analyzing the glucose-induced insulin secretion using a control theory. To validate the model, experimental data obtained in the isolated rat pancreatic islet perifusion system were compared with the simulation results. The simulation study of the model fit quite well to insulin responses under various experimental conditions. A glucose-induced insulin secretion from pancreatic islet .beta. cells was expressed as a function of proportional plus derivative response to glucose input with the 1st order time lag. And the negative rate of change in glucose concentration suppressed insulin secretion to the extent of the negative stimuli, regardless of glucose concentration. This model would be useful as a research tool for analysis of physiological significance of insulin secretory dynamics and clinical investigation of insulin secretion.