First Report of Macrolide Resistance Gene erm(T) Harbored by a Novel Small Plasmid from Erysipelothrix rhusiopathiae
First Report of Macrolide Resistance Gene erm(T) Harbored by a Novel Small Plasmid from Erysipelothrix rhusiopathiae
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DOI：
10.1128/aac.00228-15
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发表时间：
2015-04-01
影响因子：
4.9
通讯作者：
Wang, Hong-Ning
中科院分区：
文献类型：
--
作者：
Xu, Chang-Wen;Zhang, An-Yun;Wang, Hong-Ning
首次从我国猪源丹毒丝菌分离株中鉴定出大环内酯类耐药基因Ⅶ（T）。新型3，749-bp小质粒pER 29携带erm（T），G + C含量为31%，有四个不同的开放阅读框。pER 29的存在使克林霉素和红霉素对大肠杆菌的MIC增加至少128倍。红斑病pER 29基因的适应度成本可能是导致大肠杆菌中低频率的T基因的主要原因。红斑病
The macrolide resistance gene erm(T) was identified for the first time in a porcine Erysipelothrix rhusiopathiae isolate from swine in China. The novel 3,749-bp small plasmid pER29, which carries erm(T), had a G + C content of 31% and four distinct open reading frames. The presence of pER29 increased by at least 128-fold the MICs of clindamycin and erythromycin for E. rhusiopathiae. The fitness cost of pER29 could be responsible for the low frequency of erm(T) in E. rhusiopathiae.