Compartmental modeling of skin transport
Compartmental modeling of skin transport
复制标题
DOI：
10.1016/j.ejpb.2018.07.015
复制
发表时间：
2018-09-01
影响因子：
4.9
通讯作者：
Anissimov, Y. G.
中科院分区：
文献类型：
--
作者：
Amarah, A. A.;Petlin, D. G.;Anissimov, Y. G.
本研究的主要目的是介绍一个简单而灵活的数学方法，模型运输过程中的皮肤使用隔间。所提出的方法的主要特点是，室之间的交换速率常数来自生理相关的扩散运输参数。这允许速率常数的更好的物理解释，并限制了房室模型的参数数量。所得到的房室解决方案是在良好的协议与以前公布的皮肤扩散模型的解决方案时，使用十个或更多的隔间。结果发现，新的房室模型与三个房室提供了一个更好的拟合先前公布的水渗透数据比扩散模型。两种特殊情况下，它是难以实现的扩散模型被认为是使用我们的房室方法。在这两种情况下，房室模型预测与扩散模型一致。
The primary objective of this study is to introduce a simple and flexible mathematical approach which models transport processes in skin using compartments. The main feature of the presented approach is that the rate constants for exchange between compartments are derived from physiologically relevant diffusional transport parameters. This allows for better physical interpretation of the rate constants, and limits the number of parameters for the compartmental model. The resulting compartmental solution is in good agreement with previously published solutions for the diffusion model of skin when ten or more compartments are used. It was found that the new compartmental model with three compartments provided a better fit of the previously publish water penetration data than the diffusion model. Two special cases for which it is difficult to implement the diffusion model were considered using our compartmental approach. In both cases the compartmental model predictions agreed well with the diffusion model.